Adıgüzel Fikriye Işıl, Altınkaya Serhat, Kükrer Sadık, Nessar Ahmet Zeki, Uysal Gülsüm, Adıgüzel Cevdet
Department of Obstetrics and Gynecology, Adana City Training and Research Hospital, Adana, Turkey.
Department of Obstetrics and Gynecology, Antalya City Hospital, Antalya, Turkey.
BMC Pregnancy Childbirth. 2025 Mar 21;25(1):331. doi: 10.1186/s12884-025-07399-1.
We conducted our study to investigate the relationships between hyperemesis gravidarum (HEG) and inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR).
A total of 150 pregnant women diagnosed with HEG and 150 controls were included in our study. The data analysed included demographic variables, complete blood count results, and urinary ketonuria levels.
We found that the NLR, PLR and MLR were significantly greater in HEG patients than in controls (p < 0.05), indicating a potential role of systemic inflammation in the pathophysiology of HEG. Receiver operating characteristic (ROC) analysis revealed that these markers had moderate discriminative power, suggesting their utility as adjunctive diagnostic tools in clinical settings. However, no correlation was found between inflammatory markers and the severity of ketonuria.
The NLR, PLR and MLR can be used as indicators of HEG as a result of the inflammatory process in pregnant women with HEG.
我们开展本研究以调查妊娠剧吐（HEG）与炎症标志物之间的关系，如中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及单核细胞与淋巴细胞比值（MLR）。
本研究纳入了150例诊断为妊娠剧吐的孕妇和150例对照。分析的数据包括人口统计学变量、全血细胞计数结果和尿酮尿水平。
我们发现，妊娠剧吐患者的NLR、PLR和MLR显著高于对照组（p < 0.05），表明全身炎症在妊娠剧吐的病理生理学中可能起作用。受试者工作特征（ROC）分析显示，这些标志物具有中等鉴别能力，表明它们在临床环境中作为辅助诊断工具的实用性。然而，未发现炎症标志物与酮尿严重程度之间存在相关性。
由于妊娠剧吐孕妇存在炎症过程，NLR、PLR和MLR可作为妊娠剧吐的指标。
