Zeng Xiao-Hua, Zhu Shi-Qin, Zhang Xing-Ming, Luo Wen-Jun, Li Sheng-Wei
Department of General Surgery, Second clinical College, Chongqing University of Medical Sciences, Chongqing 400010, China.
Hepatobiliary Pancreat Dis Int. 2002 Feb;1(1):140-2.
To explore the changes of plasma endothelin (ET) and nitric oxide (NO) levels in patients with acute pancreatitis.
The level of plasma ET was measured by radioactive-immunoassay, and NO by spectrophotometry.
The levels of ET, NO and the ET/NO ratio in patients with severe acute pancreatitis (SAP) within 24 hours in hospital were all significantly higher than those in other groups of patients [(176+/-8) pg/ml, (97+/-11) micromol/L, and 1.83+/-0.12, P<0.01]. Compared to healthy controls (N), the levels of ET and NO in patients without pancreatitis acute abdomen (NAP) and patients with mild acute pancreatitis (MAP) increased significantly (P<0.01). After appropriate treatment, the levels of ET and NO in the MAP group were lower (P<0.01). Compared with those before treatment, the levels of ET and NO in the SAP group on the 3rd and 7th day in hospital dropped significantly (P<0.01). The ET/NO ratio on the 7th day was also lower than that on admission (P<0.01).
The malfunction of endothelial cells and the increased ET/NO ratio may be related to the mechanism of pancreatic microcirculatory disturbance in patients with SAP; early dynamic determination of these parameters may help predict the prognosis of SAP.
探讨急性胰腺炎患者血浆内皮素（ET）和一氧化氮（NO）水平的变化。
采用放射免疫法测定血浆ET水平，用分光光度法测定NO水平。
重症急性胰腺炎（SAP）患者入院24小时内ET、NO水平及ET/NO比值均显著高于其他组患者[（176±8）pg/ml、（97±11）μmol/L、1.83±0.12，P<0.01]。与健康对照组（N）相比，非胰腺炎急性腹痛（NAP）患者和轻症急性胰腺炎（MAP）患者的ET和NO水平显著升高（P<0.01）。经过适当治疗后，MAP组的ET和NO水平降低（P<0.01）。与治疗前相比，SAP组患者入院第3天和第7天的ET和NO水平显著下降（P<0.01）。第7天的ET/NO比值也低于入院时（P<0.01）。
内皮细胞功能障碍及ET/NO比值升高可能与SAP患者胰腺微循环障碍机制有关；早期动态测定这些参数可能有助于预测SAP的预后。
