Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, People's Republic of China.
Eur J Gastroenterol Hepatol. 2012 May;24(5):501-5. doi: 10.1097/MEG.0b013e328350f8fd.
To investigate the role of group-specific component globulin (Gc-globulin) in the early process of severe acute pancreatitis (SAP).
A total of 37 patients with SAP and 31 patients with mild acute pancreatitis (MAP) were enrolled in the study. Twenty healthy individuals served as controls. Blood samples were taken from SAP and MAP patients on the day of admission (day 1), day 7, and day 14. Serum total Gc-globulin levels were measured using an enzyme-linked immunosorbent assay.
On admission, the total Gc-globulin levels of patients in the SAP group were 368 (270-455) mg/l (expressed as medians with interquartile range), which were significantly lower (P=0.007) compared with the control group [420 (299-585) mg/l]. In the SAP group, a significant decrease in serum total Gc-globulin was observed in patients who developed organ dysfunction [267 (242-306) mg/l] compared with patients who did not [414 (329-513) mg/l, P<0.001]. Patients with lower Gc-globulin levels were at a higher risk of developing organ dysfunction (P=0.005). Furthermore, serial measurements displayed increasing total Gc-globulin levels in survivors.
Decreased total Gc-globulin was linked to poor outcomes of SAP. These data support our hypothesis that Gc-globulin may play an important role in the early process of acute pancreatitis. Gc-globulin might be a novel target for prognosis and therapy of SAP.
探讨特异性球蛋白（Gc-globulin）在重症急性胰腺炎（SAP）早期过程中的作用。
共纳入 37 例 SAP 患者和 31 例轻症急性胰腺炎（MAP）患者，另选 20 例健康个体作为对照。SAP 和 MAP 患者分别于入院当天（第 1 天）、第 7 天和第 14 天采集血样，采用酶联免疫吸附试验检测血清总 Gc-globulin 水平。
入院时，SAP 组患者的总 Gc-globulin 水平为 368（270455）mg/L（中位数，四分位距），显著低于对照组[420（299585）mg/L，P=0.007]。在 SAP 组中，发生器官功能障碍的患者血清总 Gc-globulin 水平明显下降[267（242306）mg/L]，而未发生器官功能障碍的患者则无明显下降[414（329513）mg/L，P<0.001]。低 Gc-globulin 水平患者发生器官功能障碍的风险更高（P=0.005）。此外，连续测量显示，幸存者的总 Gc-globulin 水平逐渐升高。
总 Gc-globulin 降低与 SAP 不良预后相关。这些数据支持我们的假说，即 Gc-globulin 可能在急性胰腺炎的早期过程中发挥重要作用。Gc-globulin 可能成为 SAP 预后和治疗的新靶点。
