Inagaki T, Yamamoto T, Nokura K, Hashizume Y, Niimi T, Hasegawa R, Ojika K, Yamamoto M
Department of Internal Medicine, Nagoya-shi Koseiin Geriatric Hospital.
Nihon Ronen Igakkai Zasshi. 1992 Oct;29(10):729-34. doi: 10.3143/geriatrics.29.729.
The purpose of this study was to clarify the prognosis of senile dementia based on a 5-year follow-up study in institutions for the elderly. The subjects consisted of 747 cases over 60 years of age. Of these 316 cases showed clinical dementia but 431 cases had no intellectual disturbance in July, 1987. The mortality rate (56.3%) of the demented group was significantly higher than that (31.8%) of the non-demented group. The mortality rate of patients increased with aging. However, the mortality rate of the demented group did not correlate with the severity of dementia. An autopsy study revealed that the direct causes of death in 51.1% of demented patients were pneumonia and cardiovascular diseases. Among the demented patients followed up for 5 years, 22.5% showed severe worsening of dementia, 25.8% showed slight or moderate degree of worsening and 51.7% showed no change. Factors causing exacerbation of dementia included cerebrovascular disease and bone fracture.
本研究旨在通过对老年机构中为期5年的随访研究，阐明老年痴呆症的预后情况。研究对象包括747例60岁以上的老人。1987年7月，其中316例表现出临床痴呆症状，而431例没有智力障碍。痴呆组的死亡率（56.3%）显著高于非痴呆组（31.8%）。患者的死亡率随年龄增长而上升。然而，痴呆组的死亡率与痴呆严重程度无关。尸检研究表明，51.1%的痴呆患者直接死因是肺炎和心血管疾病。在随访5年的痴呆患者中，22.5%的患者痴呆症状严重恶化，25.8%的患者症状有轻微或中度恶化，51.7%的患者症状无变化。导致痴呆症加重的因素包括脑血管疾病和骨折。
