Heukelbach J, Eisele M, Jackson A, Feldmeier H
Mandacaru Foundation, Rua José Vilar de Andrade 257, Fortaleza, CE 60833-830, Brazil.
Ann Trop Med Parasitol. 2003 Oct;97(7):743-9. doi: 10.1179/000349803225002408.
Tungiasis is caused by the penetration of the female sand flea Tunga penetrans into the epidermis of its host. Human infestation with this ectoparasite is hyper-endemic in many resource-poor communities in sub-Saharan Africa, the Caribbean and South America and is associated with considerable morbidity. Currently, there is no effective drug available to treat tungiasis (or at least none for which a parasiticidal effect has been clearly demonstrated). In an attempt to fill this gap, the effects of treatment with topical ivermectin (lotion), thiabendazole (ointment and lotion), metrifonate (lotion) or placebo lotion were compared in a randomized trial. A total of 108 subjects with 169 tungiasis-infested feet participated in the study. The results show that topical ivermectin, metrifonate or thiabendazole can each significantly reduce the number of lesions caused by embedded sand fleas. Further studies are needed to optimise the doses and administration of these compounds.
潜蚤病是由雌性穿皮潜蚤侵入宿主表皮所致。在撒哈拉以南非洲、加勒比地区和南美洲的许多资源匮乏社区，人类感染这种体外寄生虫的情况极为普遍，且与相当高的发病率相关。目前，尚无有效的药物可用于治疗潜蚤病（或者至少没有一种药物的杀寄生虫效果得到明确证实）。为了填补这一空白，在一项随机试验中比较了局部使用伊维菌素（洗剂）、噻苯达唑（软膏和洗剂）、敌百虫（洗剂）或安慰剂洗剂的治疗效果。共有108名受试者、169只感染潜蚤病的足部参与了该研究。结果表明，局部使用伊维菌素、敌百虫或噻苯达唑均可显著减少嵌入沙蚤引起的损伤数量。需要进一步研究以优化这些化合物的剂量和给药方式。
