Despret S, Dinh L, Clément M, Bourre J M
INSERM U 26, Hôpital Fernand Widal, Paris, France.
Neurosci Lett. 1992 Sep 28;145(1):19-22. doi: 10.1016/0304-3940(92)90193-b.
delta-6 Desaturase, measured at substrate saturation using linoleic acid, was found to be increased by more than two-fold when the content of vitamin E in brain microsomal membrane suspension was increased (up to 7.5 micrograms/mg membrane protein, i.e. 100 micrograms/g tissue from which microsomes were prepared). In contrast, this activity was reduced by 25% in the liver. This raises the question of the multiple role of vitamin E in membranes, the control of membrane polyunsaturated fatty acids through synthesis, and their protection against peroxidation.
使用亚油酸在底物饱和状态下测得的δ-6去饱和酶，当脑微粒体膜悬浮液中维生素E含量增加（高达7.5微克/毫克膜蛋白，即从制备微粒体的组织中每克100微克）时，其活性增加了两倍多。相比之下，肝脏中的这种活性降低了25%。这就提出了维生素E在膜中的多种作用、通过合成对膜多不饱和脂肪酸的控制以及它们对过氧化的保护作用等问题。
