Brusic V, Millot M, Petrovsky N, Gendel S M, Gigonzac O, Stelman S J
Institute for Infocomm Research, Singapore.
Allergy. 2003 Nov;58(11):1093-100. doi: 10.1034/j.1398-9995.2003.00248.x.
Allergies represent a significant medical and industrial problem. Molecular and clinical data on allergens are growing exponentially and in this article we have reviewed nine specialized allergen databases and identified data sources related to protein allergens contained in general purpose molecular databases. An analysis of allergens contained in public databases indicates a high level of redundancy of entries and a relatively low coverage of allergens by individual databases. From this analysis we identify current database needs for allergy research and, in particular, highlight the need for a centralized reference allergen database.
过敏反应是一个重大的医学和工业问题。关于过敏原的分子和临床数据呈指数级增长,在本文中,我们回顾了九个专门的过敏原数据库,并确定了与通用分子数据库中所含蛋白质过敏原相关的数据源。对公共数据库中所含过敏原的分析表明,条目的冗余度很高,而各个数据库对过敏原的覆盖相对较低。通过这项分析,我们确定了当前过敏研究对数据库的需求,特别是强调了建立一个集中式参考过敏原数据库的必要性。