基底细胞癌的流行病学与病因学

Epidemiology and aetiology of basal cell carcinoma.

作者信息

Tran H, Chen K, Shumack S

机构信息

Department of Dermatology, St George Hospital, University of NSW, Sydney, Australia.

出版信息

Br J Dermatol. 2003 Nov;149 Suppl 66:50-2. doi: 10.1046/j.0366-077x.2003.05622.x.

DOI:10.1046/j.0366-077x.2003.05622.x

PMID:14616351

Abstract

Basal cell carcinoma is the most common malignancy among caucasians worldwide. Accurate epidemiological data can be difficult to obtain, but does suggest that the overall incidence is increasing. Risk factors include skin type, prior skin cancers and immunosuppression. Research in free radical-mediated cellular injury and innate defence mechanisms, and ultraviolet radiation-induced genetic mutations have improved our understanding of the development of this disorder.

摘要

基底细胞癌是全球白种人中最常见的恶性肿瘤。准确的流行病学数据可能难以获取，但确实表明总体发病率在上升。风险因素包括皮肤类型、既往皮肤癌和免疫抑制。对自由基介导的细胞损伤和先天防御机制以及紫外线辐射诱导的基因突变的研究，增进了我们对这种疾病发生发展的理解。