Mannweiler Sebastian, Beham Alfred, Langner Cord
Institute of Pathology, University of Graz, Medical School, Graz, Austria.
APMIS. 2003 Oct;111(10):978-84. doi: 10.1034/j.1600-0463.2003.1111010.x.
The expression of MUC1 and MUC2 was studied in salivary gland tumors and non-neoplastic salivary gland tissue. Formalin-fixed paraffin-embedded specimens from 101 patients (21 pleomorphic adenomas (PA), 22 Warthin's tumors (WT), 26 adenoid cystic carcinomas (ACC), 13 acinic cell adenocarcinomas (ACA), 9 mucoepidermoid carcinomas (MC), and 10 specimens of non-neoplastic parotid and submandibular gland tissue) were immunostained. All salivary gland tumors expressed MUC1. A strong immunoreactivity was noted in WT and MC, a moderate in ACC and ACA, and a weak in PA. Strong expression of MUC2 was noted in all WT, moderate expression in MC, and weak expression in PA and ACA. All cases of ACC except for two were negative for MUC2. In general, MUC1 expression was stronger than that of MUC2. Non-neoplastic salivary gland tissue revealed a moderate MUC1 and MUC2 expression in excretory ducts and a strong expression in striated ducts. The apical plasma membrane of some serous acini expressed MUC1. Mucous acini were negative for both antigens. No change in immunoreactivity was noted in cases of chronic sclerosing sialadenitis. In conclusion, the different expression pattern of MUC1 and MUC2 in salivary gland neoplasia may be of additional value for the classification of salivary gland tumors.
研究了唾液腺肿瘤及非肿瘤性唾液腺组织中MUC1和MUC2的表达情况。对101例患者的福尔马林固定石蜡包埋标本（21例多形性腺瘤（PA）、22例沃辛瘤（WT）、26例腺样囊性癌（ACC）、13例腺泡细胞腺癌（ACA）、9例黏液表皮样癌（MC）以及10例非肿瘤性腮腺和颌下腺组织标本）进行免疫染色。所有唾液腺肿瘤均表达MUC1。WT和MC中观察到强免疫反应性，ACC和ACA中为中度，PA中为弱免疫反应性。WT中均观察到MUC2的强表达，MC中为中度表达，PA和ACA中为弱表达。除2例ACC外，所有ACC病例的MUC2均为阴性。总体而言，MUC1的表达强于MUC2。非肿瘤性唾液腺组织在排泄管中显示中度MUC1和MUC2表达，在纹状管中为强表达。一些浆液性腺泡的顶端质膜表达MUC1。黏液性腺泡对两种抗原均为阴性。慢性硬化性涎腺炎病例中未观察到免疫反应性变化。总之，MUC1和MUC2在唾液腺肿瘤中的不同表达模式可能对唾液腺肿瘤的分类具有额外价值。
