Triantafyllou Asterios, Thompson Lester D R, Devaney Kenneth O, Bell Diana, Hunt Jennifer L, Rinaldo Alessandra, Vander Poorten Vincent, Ferlito Alfio
Oral and Maxillofacial Pathology, School of Dentistry, University of Liverpool, Liverpool, UK.
Head Neck Pathol. 2015 Sep;9(3):387-404. doi: 10.1007/s12105-014-0581-1. Epub 2014 Nov 8.
The complex microstructure of salivary gland pleomorphic adenoma is examined in relation to function. Events related to secretion of macromolecules and absorption, responses to the altered microenvironment and controversies concerning epithelial-mesenchymal transition versus modified myoepithelial differentiation are explored. Their effects on tumor cell phenotypes and arrangements are emphasized. Heterotopic differentiation and attempts at organogenesis are also considered. The approach allows interpreting microstructure independently of histogenetic perceptions, envisaging the tumor cells as a continuum, endorsing luminal structures as the principal components, and defining pleomorphic adenoma as a benign epithelial tumour characterized by variable epithelial-mesenchymal transition, secretion/differentiation and metaplasia.
研究唾液腺多形性腺瘤的复杂微观结构与功能的关系。探讨了与大分子分泌和吸收相关的事件、对改变的微环境的反应以及关于上皮-间质转化与修饰的肌上皮分化的争议。强调了它们对肿瘤细胞表型和排列的影响。还考虑了异位分化和器官发生的尝试。该方法允许独立于组织发生学观念来解释微观结构，将肿瘤细胞视为一个连续体，认可管腔结构为主要成分，并将多形性腺瘤定义为一种良性上皮肿瘤，其特征为可变的上皮-间质转化、分泌/分化和化生。
