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HLA-B*5808, a new HLA-B allele characterized by sequence based typing.

作者信息

Poli F, Crespiatico L, Frison S, Longhi E, Marlianici E, Scalamogna M

机构信息

Centro Trasfusionale e di Immunologia dei Trapianti, Ospedale Maggiore Policlinico IRCCS, Milano, Italy.

出版信息

Tissue Antigens. 2003 Dec;62(6):551-3. doi: 10.1046/j.1399-0039.2003.00111.x.

DOI:10.1046/j.1399-0039.2003.00111.x
PMID:14617040
Abstract

This brief communication describes a new HLA-B allele (HLA-B5808) detected in an Italian white volunteer bone marrow donor. With serology, this subject was typed as HLA-B15,17, whereas with molecular biology B15, B51, B52 and/or B58 could be assigned. In order to clarify the results, direct and cloning sequencing of exons 2, 3 and 4 were carried out. This new allele is identical to HLA-B5801 in exon 2 except for a silent point mutation at nucleotide 141 where a C is substituted by a T; exons 3 and 4 are typical of HLA-B51, B52 and B78. The peculiar sequence of B5808 could explain the discrepancy between the serological and molecular typing results.

摘要

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