Rice Kelly C, Bayles Kenneth W
Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, ID 83844-3052, USA.
Mol Microbiol. 2003 Nov;50(3):729-38. doi: 10.1046/j.1365-2958.2003.t01-1-03720.x.
Programmed cell death (PCD) is a genetically determined process of cellular suicide that is activated in response to cellular stress or damage, as well as in response to the developmental signals in multicellular organisms. Although historically studied in eukaryotes, it has been proposed that PCD also functions in prokaryotes, either during the developmental life cycle of certain bacteria or to remove damaged cells from a population in response to a wide variety of stresses. This review will examine several putative examples of bacterial PCD and summarize what is known about the molecular components of these systems.
程序性细胞死亡（PCD）是一种由基因决定的细胞自杀过程，它在细胞受到应激或损伤时被激活，同时也响应多细胞生物体中的发育信号。尽管历史上对真核生物进行了研究，但有人提出PCD在原核生物中也起作用，要么在某些细菌的发育生命周期中起作用，要么在应对各种应激时从群体中清除受损细胞。本综述将研究细菌PCD的几个假定例子，并总结关于这些系统分子成分的已知信息。
