门诊使用离子选择电极测定静脉全血和毛细血管全血中的锂含量。

Lithium determination in outpatient clinics by an ion-selective electrode in venous and capillary whole blood.

作者信息

Greil W, Steller B

机构信息

Psychiatric Hospital, University of Munich, Germany.

出版信息

Psychiatry Res. 1992 Oct;44(1):71-7. doi: 10.1016/0165-1781(92)90071-a.

DOI:10.1016/0165-1781(92)90071-a

PMID:1461949

Abstract

The use of an ion-selective electrode (ISE) to determine lithium (Li) in routine clinical application was evaluated by repeatedly analyzing reference specimens (precision evaluation) and by comparing blood concentrations in Li-treated patients assessed by ISE and flame emission spectrometry (FES) (correlation and agreement). Precision evaluation was sufficiently high. Li values determined by ISE in venous and capillary whole blood showed high correlations with FES plasma values (correlation coefficients between 0.86 and 0.99). Within the therapeutic range (0.3-1.0 mmole/l Li), agreement was sufficient for venous and less satisfactory for capillary blood (mean differences, FES minus ISE: -0.03 and -0.11 mmole/l Li). Above the therapeutic range, ISE values markedly exceeded FES results.

摘要

通过反复分析参考标本（精密度评估）以及比较用离子选择电极（ISE）和火焰发射光谱法（FES）评估的锂治疗患者的血药浓度（相关性和一致性），对ISE在常规临床应用中测定锂（Li）的情况进行了评估。精密度评估足够高。ISE测定的静脉全血和毛细血管全血中的锂值与FES测定的血浆值高度相关（相关系数在0.86至0.99之间）。在治疗范围内（0.3 - 1.0毫摩尔/升锂），静脉血的一致性足够，而毛细血管血的一致性较差（平均差异，FES减去ISE：-0.03和-0.11毫摩尔/升锂）。高于治疗范围时，ISE值明显超过FES结果。