Nichols Kelly K, Nichols Jason J, Lynn Mitchell G
The Ohio State University, College of Optometry, 320 West 10th Avenue PO Box 182342, Columbus, OH 43218-2342, USA.
Ophthalmic Physiol Opt. 2003 Nov;23(6):553-60. doi: 10.1046/j.1475-1313.2003.00153.x.
The purpose of this report was to investigate the relation between dry eye diagnostic tests.
Dry eye patients were enrolled to complete a clinical examination, including the following dry eye tests: a meibomian gland evaluation, tear meniscus height, fluorescein tear breakup time, fluorescein staining of the cornea, the Schirmer 1 test, the phenol red thread test, and rose bengal staining of the conjunctiva. Statistical analyses, including correlation coefficients, the Wilcoxon sign rank test, chi-square test, and logistic regression were used to address the relation between these clinical tests of dry eye.
There was a strong relation between the Schirmer test and fluorescein staining in all four statistical analyses. Similarly, there was also a strong relation between the phenol red thread test and both fluorescein and rose bengal staining. Finally, the results of the Schirmer test were associated with the tear breakup time test in three of four analyses.
The results indicate that tests of aqueous deficiency (volume or production) are associated with ocular surface desiccation. This important relation should be recognized when choosing dry eye tests as outcomes in clinical trials and epidemiological studies.
本报告旨在研究干眼诊断测试之间的关系。
招募干眼患者完成一项临床检查，包括以下干眼测试：睑板腺评估、泪河高度、荧光素泪膜破裂时间、角膜荧光素染色、Schirmer 1试验、酚红棉线试验和结膜虎红染色。采用包括相关系数、Wilcoxon符号秩检验、卡方检验和逻辑回归在内的统计分析方法来探讨这些干眼临床测试之间的关系。
在所有四项统计分析中，Schirmer试验与荧光素染色之间存在密切关系。同样，酚红棉线试验与荧光素染色和虎红染色之间也存在密切关系。最后，在四项分析中的三项中，Schirmer试验结果与泪膜破裂时间测试相关。
结果表明，泪液缺乏（量或产生）测试与眼表干燥有关。在选择干眼测试作为临床试验和流行病学研究的结果时，应认识到这一重要关系。
