Ohio State University, College of Optometry, Columbus, Ohio, USA.
Invest Ophthalmol Vis Sci. 2011 Feb 28;52(2):1127-37. doi: 10.1167/iovs.10-5757. Print 2011 Feb.
The purpose of this study was to examine ocular surface and tear film, contact lens, care solution, medical, and patient-related factors that are associated with corneal staining in contact lens wearers.
In this cross-sectional/nested case-control study, in addition to the assessment of corneal staining with fluorescein, a variety of tear film and ocular surface, contact lens, and patient-related factors were examined. Poisson regression models were used to examine the relation between corneal staining and these factors.
Data from 413 patients were eligible for the analyses described. The average age was 30.6 ± 11.1 years, and 277 (67.1%) of the patients were women. Several factors were shown to be related to increased corneal staining in multivariate modeling, including increased daily wearing times (P = 0.0006), lower income (P = 0.0008), lissamine green conjunctival staining (P = 0.002), contact lens deposition (P = 0.007), increased tear meniscus height (P = 0.007), and decreased hydrogel nominal water content (P = 0.02). The wearing of silicone hydrogels (as opposed to hydrogels) was protective against corneal staining (P = 0.0004). Notably, neither contact lens care solutions nor disinfectants were associated with corneal staining.
Corneal staining in contact lens wearers continues to be a frequent, but not well understood, outcome. These data suggest that contact lens factors (water content, material, wearing time, and deposition) are more generally associated with corneal staining than are contact lens care solutions or other ocular surface and tear film, demographic, or medical factors.
本研究旨在探讨与接触镜佩戴者角膜染色相关的眼表和泪膜、接触镜、护理液、医疗及患者相关因素。
在这项横断面/巢式病例对照研究中，除了评估荧光素染色外，还检查了各种泪膜和眼表、接触镜和患者相关因素。使用泊松回归模型来研究角膜染色与这些因素之间的关系。
符合本研究描述的 413 名患者的数据可用于分析。平均年龄为 30.6±11.1 岁，277 名（67.1%）患者为女性。多变量建模显示，一些因素与角膜染色增加相关，包括每日佩戴时间增加（P=0.0006）、收入较低（P=0.0008）、丽丝胺绿结膜染色（P=0.002）、接触镜沉积物（P=0.007）、泪膜高度增加（P=0.007）和水凝胶名义含水量降低（P=0.02）。与水凝胶相比，硅水凝胶（P=0.0004）的佩戴可预防角膜染色。值得注意的是，接触镜护理液和消毒剂均与角膜染色无关。
接触镜佩戴者的角膜染色仍然是一种常见但尚未被充分了解的后果。这些数据表明，接触镜因素（含水量、材料、佩戴时间和沉积物）与角膜染色的相关性比接触镜护理液或其他眼表和泪膜、人口统计学或医疗因素更为普遍。
