Doheny Eye Institute, and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Cornea. 2012 Jun;31(6):680-5. doi: 10.1097/ICO.0b013e3182261577.
To measure the correlation between subjective symptom score, conventional clinical tests, and Fourier-domain optical coherence tomography (FD-OCT) of lower tear meniscus parameters in patients with dry eye disease.
Eighteen patients with dry eye disease requiring medical therapy and/or punctal occlusion were recruited for this prospective, nonrandomized, observational case series. Severity of symptoms of dry eye disease was assessed using the Indiana University Dry Eye Questionnaire 2002. Clinical assessments were completed using slit-lamp biomicroscopy, rose bengal dye staining, fluorescein tear breakup time (TBUT), and a 5-minute Schirmer test with topical anesthesia. The lower tear meniscus was imaged using an FD-OCT system with 5-μm axial resolution and measured manually by a masked grader using computer calipers. Correlation was assessed using Spearman correlation coefficient (ρ).
The mean (±SD) scaled symptom score was 58 ± 21, with a range of 0 to 100. Vital staining test averaged 1.7 ± 3.4, TBUT averaged 4.4 ± 1.8 seconds, and Schirmer tests averaged 10.2 ± 8.1 mm. As determined by optical coherence tomography, the meniscus height was 228 ± 153 μm, depth was 127 ± 79 μm, and cross-sectional area was 0.018 ± 0.021 mm. Optical coherence tomography meniscus area was negatively correlated with the symptom questionnaire score (P < 0.01) and positively correlated with Schirmer test results (P < 0.01). There was no significant correlation between symptom score and rose bengal staining, TBUT, or Schirmer test results (P > 0.01).
Lower tear meniscus measurement with FD-OCT is an objective noninvasive test that correlates well with symptoms of dry eye disease and the Schirmer test.
测量干眼症患者的主观症状评分、常规临床检查和泪膜下低凹参数的傅里叶域光学相干断层扫描（FD-OCT）之间的相关性。
本前瞻性、非随机、观察性病例系列研究纳入了 18 名需要药物治疗和/或泪点阻塞的干眼症患者。采用印第安纳大学干眼症问卷 2002 评估干眼症的严重程度。临床评估包括裂隙灯生物显微镜检查、玫瑰红染色、荧光素泪膜破裂时间（TBUT）和 5 分钟表面麻醉下的 Schirmer 测试。使用具有 5μm 轴向分辨率的 FD-OCT 系统对下泪膜下低凹进行成像，并由一名受蒙蔽的分级员使用计算机卡尺手动测量。使用 Spearman 相关系数（ρ）评估相关性。
平均（±SD）评分量表症状评分 58±21，范围 0 至 100。荧光素染色测试平均 1.7±3.4，TBUT 平均 4.4±1.8 秒，Schirmer 测试平均 10.2±8.1mm。根据光学相干断层扫描，低凹高度为 228±153μm，深度为 127±79μm，横截面积为 0.018±0.021mm。光学相干断层扫描低凹面积与症状问卷评分呈负相关（P<0.01），与 Schirmer 测试结果呈正相关（P<0.01）。症状评分与荧光素染色、TBUT 或 Schirmer 测试结果之间无显著相关性（P>0.01）。
FD-OCT 测量下泪膜下低凹是一种客观的非侵入性测试，与干眼症的症状和 Schirmer 测试相关性良好。
