Willis William D, Zhang Xijing, Honda Christopher N, Giesler Glenn J
Department of Anatomy & Neuroscience, University of Texas Medical Branch, Galveston, 77555-1069, USA.
J Pain. 2002 Apr;3(2):79-94. doi: 10.1054/jpai.2002.122949.
The evidence presented by Craig and his colleagues for an important projection from lamina I spinothalamic tract neurons to a renamed thalamic nucleus (the posterior part of the ventral medial nucleus or VMpo), as well as to the ventrocaudal medial dorsal and the ventral posterior inferior thalamic nuclei, is critically reviewed. Of particular concern is the denial of an important nociceptive lamina I projection to the ventrobasal complex. Contrary evidence is reviewed that strongly favors a role of spinothalamic projections from both lamina I and deep layers of the dorsal horn to the ventrobasal complex and other thalamic nuclei and from there to the SI and SII somatosensory cortices in the sensory-discriminative processing of pain and temperature information.
克雷格及其同事提出的证据表明，从脊髓背角I层的脊髓丘脑束神经元有重要投射至一个重新命名的丘脑核（腹内侧核后部或VMpo），以及腹尾内侧背核和丘脑腹后下核，对此进行了批判性综述。特别令人关注的是，有人否认脊髓背角I层有重要的伤害性投射至腹侧基底复合体。本文回顾了相反的证据，这些证据有力地支持了脊髓背角I层和深层的脊髓丘脑投射在疼痛和温度信息的感觉辨别处理中，从背角投射至腹侧基底复合体和其他丘脑核，再从那里投射至SI和SII体感皮层所起的作用。
