Nielsen S V, Henrichsen J
Bakteriologisk afdeling, Statens Seruminstitut, København.
Ugeskr Laeger. 1992 Nov 16;154(47):3309-12.
Streptococcus pneumoniae still causes serious infections especially in elderly people, despite relevant antibiotic treatment and intensive therapy. At present, Statens Serum-institut annually receives about 650 pneumococcal strains isolated from blood and cerebrospinal fluid for typing from the departments of Clinical Microbiology in Denmark. Of these strains about 55% were isolated from persons aged 60 years or older. The incidence of pneumococcal pneumonia in elderly people is said to be 4-8/1000 persons/year in countries similar to Denmark. In the USA, pneumococcal vaccination is recommended for groups at risk including immunocompetent adults > or = 65 years old. Since 1978, pneumococcal vaccine has been available in Denmark, where the only indication for vaccination has been and still is intended or already performed splenectomy in persons older than two years of age. According to the literature, the protective efficacy of vaccination of elderly persons is 60-70%. Since vaccination is, furthermore, without risks we believe that vaccination of elderly people in Denmark should be advised.
尽管有相关的抗生素治疗和强化治疗，但肺炎链球菌仍会引发严重感染，尤其是在老年人中。目前，丹麦国家血清研究所每年从丹麦临床微生物学部门接收约650株从血液和脑脊液中分离出来用于分型的肺炎球菌菌株。在这些菌株中，约55%是从60岁及以上的人群中分离出来的。在与丹麦类似的国家，老年人肺炎球菌肺炎的发病率据说是每年4-8/1000人。在美国，建议对包括65岁及以上免疫功能正常的成年人在内的高危人群接种肺炎球菌疫苗。自1978年以来，丹麦已有肺炎球菌疫苗，在丹麦，接种疫苗的唯一指征过去是现在仍然是两岁以上人群有意进行或已经进行的脾切除术。根据文献，老年人接种疫苗的保护效力为60%-70%。此外，由于接种疫苗没有风险，我们认为应该建议丹麦的老年人接种疫苗。
