Goel S K, Sharma S, Singh U S
Central Research Institute, Kasauli 173 204, India.
Biologicals. 2003 Dec;31(4):233-6. doi: 10.1016/s1045-1056(03)00059-9.
Rabies is endemic in India. The post exposure treatment of class three bite cases, as recommended by the World Health Organization, must involve the use of rabies immunoglobulin as soon as possible and up to the seventh day of start of anti rabies vaccination. The annual requirement in India as projected by the Ministry of Health, Government of India is about 1500 liters of purified anti rabies serum (ERIG). Central Research Institute (CRI), Kasauli, being the sole producer of ERIG in India, an effort was made to increase the production of ERIG by the use of tissue culture vaccine (Human) for primary immunization of equines. It also involved changing the vaccine from horse brain suspension to tissue culture vaccine by eliminating horse sacrifice for antigen preparation. A better immune response was obtained.
狂犬病在印度呈地方性流行。按照世界卫生组织的建议，三级咬伤病例的暴露后治疗必须尽快使用狂犬病免疫球蛋白，且在开始接种狂犬病疫苗后的第七天内都可使用。据印度政府卫生部预计，印度每年对纯化抗狂犬病血清（ERIG）的需求量约为1500升。位于卡萨利的中央研究所（CRI）是印度ERIG的唯一生产商，该机构努力通过使用组织培养疫苗（人用）对马进行初次免疫来提高ERIG的产量。这还涉及通过不再宰杀马匹制备抗原，将疫苗从马脑悬液改为组织培养疫苗。由此获得了更好的免疫反应。
