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Int J Hematol Oncol Stem Cell Res. 2023 Apr 1;17(2):128-131. doi: 10.18502/ijhoscr.v17i2.12652.
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Shedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for Cancer.癌症免疫抑制治疗后活的严重急性呼吸综合征冠状病毒2的脱落
N Engl J Med. 2020 Dec 24;383(26):2586-2588. doi: 10.1056/NEJMc2031670. Epub 2020 Dec 1.
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Case Study: Prolonged Infectious SARS-CoV-2 Shedding from an Asymptomatic Immunocompromised Individual with Cancer.病例研究：一名患有癌症的无症状免疫功能低下个体长期感染性严重急性呼吸综合征冠状病毒2（SARS-CoV-2）脱落。
Cell. 2020 Dec 23;183(7):1901-1912.e9. doi: 10.1016/j.cell.2020.10.049. Epub 2020 Nov 4.
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Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 Replication in an Immunocompromised Patient.免疫功能低下患者中严重急性呼吸综合征冠状病毒 2 持续复制。
J Infect Dis. 2021 Jan 4;223(1):23-27. doi: 10.1093/infdis/jiaa666.
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Genomic evidence for reinfection with SARS-CoV-2: a case study.基因组证据表明 SARS-CoV-2 再次感染：一项案例研究。
Lancet Infect Dis. 2021 Jan;21(1):52-58. doi: 10.1016/S1473-3099(20)30764-7. Epub 2020 Oct 12.
5
Addressing the Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hematopoietic Cell Transplantation: Learning Networks as a Means for Sharing Best Practices.应对 2019 年冠状病毒病（COVID-19）大流行对造血细胞移植的影响：学习网络作为分享最佳实践的手段。
Biol Blood Marrow Transplant. 2020 Jul;26(7):e147-e160. doi: 10.1016/j.bbmt.2020.04.018. Epub 2020 Apr 24.
6
Multiple myeloma and infections: a population-based study on 9253 multiple myeloma patients.多发性骨髓瘤与感染：一项基于9253例多发性骨髓瘤患者的人群研究。
Haematologica. 2015 Jan;100(1):107-13. doi: 10.3324/haematol.2014.107714. Epub 2014 Oct 24.
7
Immune reconstitution after hematopoietic cell transplantation.造血细胞移植后的免疫重建。
Curr Opin Hematol. 2012 Jul;19(4):324-35. doi: 10.1097/MOH.0b013e328353bc7d.
8
Immune parameters in multiple myeloma patients: influence of treatment and correlation with opportunistic infections.多发性骨髓瘤患者的免疫参数：治疗的影响及与机会性感染的相关性
Leuk Lymphoma. 2006 Aug;47(8):1570-82. doi: 10.1080/10428190500472503.
9
Active surveillance for respiratory virus infections in adults who have undergone bone marrow and peripheral blood stem cell transplantation.对接受骨髓和外周血干细胞移植的成年人进行呼吸道病毒感染的主动监测。
Bone Marrow Transplant. 2003 Dec;32(11):1085-8. doi: 10.1038/sj.bmt.1704257.
10
Respiratory viral infections after bone marrow/peripheral stem-cell transplantation: the Christie hospital experience.骨髓/外周血干细胞移植后的呼吸道病毒感染：克里斯蒂医院的经验
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一名接受自体干细胞移植治疗的多发性骨髓瘤患者的新型冠状病毒2型感染的非典型病程。

Atypical Course of SarsCov-2 Infection in a Patient with Multiple Myeloma Treated with Autologous Stem Cell Transplantation.

作者信息

Isaia Gianluca, Valerio Silvia, Oliva Stefania, Brunetti Enrico, Bo Mario

机构信息

Section of Geriatrics, Department of Medical Sciences, Università degli Studi di Torino, A.O.U. Città della Salute e della Scienza di Torino, Molinette, Corso Bramante 88, 10126, Turin, Italy.

Department of Oncology, Division of Hematology, A.O.U. Città della Salute e della Scienza di Torino, Torino, Italy.

出版信息

Int J Hematol Oncol Stem Cell Res. 2023 Apr 1;17(2):128-131. doi: 10.18502/ijhoscr.v17i2.12652.

DOI:10.18502/ijhoscr.v17i2.12652
PMID:37637765
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10452944/
Abstract

Covid-19 infection has more relevant consequences in frail and comorbid patients, but little is known about its course in patients with hematologic malignancies. In this report, we would like to present the case of a patient with multiple myeloma treated with recent autologous bone marrow stem cell transplantation and affected by Covid-19 pneumonia, presenting with a possible reinfection or an extremely long viral shedding.

摘要

新型冠状病毒肺炎（Covid-19）感染在体弱和合并症患者中会产生更严重的后果，但对于血液系统恶性肿瘤患者的病情发展却知之甚少。在本报告中，我们将介绍一例多发性骨髓瘤患者的病例，该患者近期接受了自体骨髓干细胞移植，并感染了Covid-19肺炎，出现了可能的再次感染或病毒长时间脱落的情况。