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欧洲成年人哮喘控制不佳的预测因素。

Predictors of poor asthma control in European adults.

作者信息

Soriano Joan B, Rabe Klaus F, Vermeire Paul A

机构信息

Worldwide Epidemiology, GlaxoSmithKline Research and Development, Greenford, Middlesex, UK.

出版信息

J Asthma. 2003;40(7):803-13. doi: 10.1081/jas-120023572.

Abstract

Asthmatics in the community suffer morbidity due to poor asthma control. The Global Initiative for Asthma (GINA) guidelines established minimum goals for the management of asthma. Our objective was to quantify the demographic and clinical factors associated with asthma control in adult asthmatics. A population sample of asthmatics 16 years and older was obtained by random digit dialing in seven European countries (France, Germany, Italy, The Netherlands, Spain, Sweden, and United Kingdom), and asthma control was quantified according to daytime and nighttime symptoms, severe episodes, and limits on daily activities due to asthma. Among the 2050 adult current asthmatics surveyed, 35% had good asthma control (0 or 1 GINA goals failed), 40% had moderate asthma control (2 or 3 GINA goals failed), and 25% had poor asthma control (4 or 5 GINA goals failed). Fewer subjects with poor than those with good asthma control had ever received a lung function test, and significantly fewer patients with poor asthma control had been taught by a doctor or nurse how to use their peak flow meter. When questioned about the underlying cause of asthma, only 7.8% of asthmatics mentioned airway inflammation, and only 17.6% stated that inhaled corticosteroids were the most effective medication for reducing airway inflammation. There was more use of quick relief bronchodilator medications in the past 4 weeks among patients with poor asthma control. Asthma management practices and the knowledge, attitudes, and behavior of adult asthmatics in the general population are associated with the degree of asthma control.

摘要

社区中的哮喘患者因哮喘控制不佳而患病。全球哮喘防治创议(GINA)指南制定了哮喘管理的最低目标。我们的目的是量化与成年哮喘患者哮喘控制相关的人口统计学和临床因素。通过在七个欧洲国家(法国、德国、意大利、荷兰、西班牙、瑞典和英国)随机拨号获得了16岁及以上哮喘患者的人群样本,并根据白天和夜间症状、严重发作以及哮喘对日常活动的限制来量化哮喘控制情况。在接受调查的2050名成年现患哮喘患者中,35%的患者哮喘控制良好(未达到0或1个GINA目标),40%的患者哮喘控制中等(未达到2或3个GINA目标),25%的患者哮喘控制不佳(未达到4或5个GINA目标)。哮喘控制不佳的患者中接受过肺功能检查的人数少于哮喘控制良好的患者,而且哮喘控制不佳的患者中由医生或护士教导如何使用峰流速仪的人数明显更少。当被问及哮喘的潜在病因时,只有7.8%的哮喘患者提到气道炎症,只有17.6%的患者表示吸入性糖皮质激素是减轻气道炎症最有效的药物。在过去4周内,哮喘控制不佳的患者更多地使用了速效支气管扩张剂药物。普通人群中成人哮喘患者的哮喘管理实践以及知识、态度和行为与哮喘控制程度相关。

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