Türkoglu Cavlan, Duman Belgin Süsleyici, Günay Demet, Cagatay Penbe, Ozcan Remzi, Büyükdevrim A Sevim
Kadir Has University, School of Medicine, Dept. of Cardiology, Istanbul, Turkey.
Obes Surg. 2003 Oct;13(5):699-705. doi: 10.1381/096089203322509255.
Metabolic syndrome includes abdominal obesity, diabetes type 2, hypertension, dyslipidemia, derangements of fibrinolysis, and atherosclerosis. Since abdominal obesity is one of the major components of the insulin resistance syndrome (IRS), an attempt was made to evaluate the interrelationships between the magnitude of obesity and the components of the syndrome.
A cross-sectional study of 123 subjects with type 2 diabetes, of whom 31 were normal body weight and 92 had varying degrees of obesity was conducted. The participants were investigated in terms of clinical and laboratory findings of IRS. Fasting and 30-min (early) plasma glucose and serum insulin excursions in response to oral glucose challenge (75 g) were determined. The peripheral and hepatic insulin resistance (insensitivity) was calculated by homeostasis model assessment (HOMA).
Clinical and biochemical findings were compared with the components of the IRS, and demonstrated that a rise in fasting as well as 30-min insulin secretion increases as abdominal body fat (obesity) increases. There was also a significant and proportional correlation between the magnitude of abdominal obesity and the components of metabolic syndrome.
Abdominal adiposity appears to have a pivotal role in the development of IRS.
代谢综合征包括腹型肥胖、2型糖尿病、高血压、血脂异常、纤溶紊乱和动脉粥样硬化。由于腹型肥胖是胰岛素抵抗综合征（IRS）的主要组成部分之一，因此我们试图评估肥胖程度与该综合征各组成部分之间的相互关系。
对123例2型糖尿病患者进行了横断面研究，其中31例体重正常，92例有不同程度的肥胖。根据IRS的临床和实验室检查结果对参与者进行调查。测定口服葡萄糖耐量试验（75g）后空腹及30分钟（早期）血浆葡萄糖和血清胰岛素变化情况。采用稳态模型评估（HOMA）计算外周和肝脏胰岛素抵抗（不敏感）。
将临床和生化检查结果与IRS的各组成部分进行比较，结果显示随着腹部体脂（肥胖）增加，空腹及30分钟胰岛素分泌均升高。腹型肥胖程度与代谢综合征各组成部分之间也存在显著的比例相关性。
腹部肥胖似乎在IRS的发生发展中起关键作用。
