Aoki K, Kamada M, Ikekita M, Kizuki K, Moriya H
Department of Biochemistry, Science University of Tokyo, Japan.
Agents Actions Suppl. 1992;38 ( Pt 2):157-64.
Rat urinary kallikrein (RUK) injected intravenously to the rat rapidly disappeared from the blood circulation and mainly distributed to the liver. RUK was also incorporated to the primary cultured rat hepatocytes. The amounts of RUK incorporated into the hepatocytes increased by preincubation of RUK with rat plasma. These results and SDS-PAGE analysis suggested some plasma components may be involved in tissue kallikrein clearance in the blood.
静脉注射给大鼠的大鼠尿激肽释放酶（RUK）迅速从血液循环中消失，主要分布到肝脏。RUK也被原代培养的大鼠肝细胞摄取。用大鼠血浆预孵育RUK后，肝细胞摄取的RUK量增加。这些结果和SDS-PAGE分析表明，一些血浆成分可能参与了血液中组织激肽释放酶的清除。
