肝脏对血浆激肽释放酶的清除作用：综述

Plasma kallikrein clearance by the liver: a review.

Borges D R, Kouyoumdjian M

Disciplina de Gastroenterologia, Escola Paulista de Medicina, São Paulo, Brasil.

Braz J Med Biol Res. 1994 Aug;27(8):2033-41.

Abstract

The liver is the main organ clearing both plasma and tissue kallikreins from the circulation. Hepatocytes are responsible for the internalization of rat plasma kallikrein (RPK) and the clearance of plasma kallikrein by the liver is Ca(2+)-independent. The binding site of RPK to the liver cell is located on its heavy chain which is not exposed on prokallikrein. An S-type lectin accounts for the receptor-mediated endocytosis of RPK. 2. These properties of the liver are affected by pathological situations, particularly the acute-phase response to inflammation, in which the kallikrein-kinin system plays a major role. The hepatic clearance of the alpha 2-macroglobulin-plasma kallikrein complex is less efficient than the clearance of the free enzyme.

摘要

肝脏是从循环系统中清除血浆和组织激肽释放酶的主要器官。肝细胞负责大鼠血浆激肽释放酶（RPK）的内化，肝脏对血浆激肽释放酶的清除不依赖于Ca(2+)。RPK与肝细胞的结合位点位于其重链上，而该重链在激肽释放酶原上并不暴露。一种S型凝集素介导了RPK的受体介导的内吞作用。2. 肝脏的这些特性会受到病理状况的影响，尤其是对炎症的急性期反应，其中激肽释放酶-激肽系统起主要作用。α2-巨球蛋白-血浆激肽释放酶复合物的肝脏清除效率低于游离酶的清除效率。