Zhang Wei-Dong, Fan Jun-Ming, Guan Jing, Peng Guo-Hui, Zhou Li, Jian Xun, Chen Ming, Liu Xiao-Hui, Zhang Pu-Sheng
Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Zhonghua Nan Ke Xue. 2003 Oct;9(7):489-93.
To investigate the prevalence, main manifestation and related factors of sexual dysfunction in male patients with chronic renal insufficiency (CRI).
A cross-section study was conducted by six hospitals in Sichuan Province. The prevalence and severity of sexual dysfunction were assessed by SCASF microsoft among patients with chronic renal disease. Logistic regression was used to examine and test the association between sexual dysfunction and other medical conditions.
The prevalence of sexual dysfunction was wider in patients with CRI than in those without. The main manifestations in male patients were decreased libido, erectile dysfunction and premature ejaculation. Stratified analysis in uremia showed that the prevalence and severity of sexual dysfunction were similar between patients on haemodialysis(HD) and those on peritoneal dialysis(PD). The patients receiving no replacement treatment suffered more decreased libido and performance anxiety than dialyzed patients (HD and PD) and transplantation patients(Tx). The patients receiving no replacement treatment and dialysis suffered more erectile dysfunction than Tx men. A multivariable analysis demonstrated that the duration, creatinine clearance(Ccr), parathyroid hormone (PTH), albumin(Alb) were not associated with sexual dysfunction. The use of beta-blocker, anemia and depression were risky factors for decreased libido, and increasing age was a risky factor for erectile dysfunction. The use of angiotensin-converting-enzyme inhibitor(ACEI)/angiotention receptor antagonist (ARB) and recombinant human erythropoietin(r-HuEpo) were protective factors for erectile dysfunction.
The main manifestations of sexual dysfunction in male patients with CRI are decreased libido, erectile dysfunction and premature ejaculation. The replacement therapy, especially transplantation, can decrease the prevalence or severity of sexual dysfunction. The genesis of sexual dysfunction is multifactorial, including age, physiological factors, psychological factors and medical conditions.
探讨慢性肾功能不全（CRI）男性患者性功能障碍的患病率、主要表现及相关因素。
四川省六家医院开展了一项横断面研究。采用SCASF microsoft评估慢性肾病患者性功能障碍的患病率和严重程度。运用逻辑回归分析来检验和测试性功能障碍与其他疾病之间的关联。
CRI患者性功能障碍的患病率高于非CRI患者。男性患者的主要表现为性欲减退、勃起功能障碍和早泄。尿毒症分层分析显示，血液透析（HD）患者和腹膜透析（PD）患者性功能障碍的患病率和严重程度相似。未接受替代治疗的患者比接受透析治疗（HD和PD）及移植治疗（Tx）的患者性欲减退和性交焦虑更为严重。未接受替代治疗和透析的患者比接受移植治疗的男性勃起功能障碍更为严重。多变量分析表明，病程、肌酐清除率（Ccr）、甲状旁腺激素（PTH）、白蛋白（Alb）与性功能障碍无关。使用β受体阻滞剂、贫血和抑郁是性欲减退的危险因素，年龄增长是勃起功能障碍的危险因素。使用血管紧张素转换酶抑制剂（ACEI）/血管紧张素受体拮抗剂（ARB）和重组人促红细胞生成素（r-HuEpo）是勃起功能障碍的保护因素。
CRI男性患者性功能障碍的主要表现为性欲减退、勃起功能障碍和早泄。替代治疗，尤其是移植治疗，可降低性功能障碍的患病率或严重程度。性功能障碍的发生是多因素的，包括年龄、生理因素、心理因素和疾病状况。
