Guan Jing, Fan Jun-ming, Zhang Wei-dong, Luo Hai, Li Zi, Peng Guo-hui, Zhou Li, Wang Wei
Department of Nephrology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2005 Jul;36(4):555-8.
To investigate the prevalence, the main manifestations and related factors of sexual dysfunction in female patients with chronic renal insufficiency (CRI).
A multi-factor cooperation cross-section study was conducted. The prevalence and severity of sexual dysfunction were assessed using SCASF Microsoft.
The prevalence of sexual dysfunction in patients with CRI was higher than that in those without renal insufficiency (P<0.05). The main manifestations in female patients were "decreased libido, lack of orgasm and no feeling of sex pleasure". Stratified analysis on uremia showed that the prevalence and severity of sexual dysfunction of the patients on hemodialysis were similar to those on peritoneum dialysis. The women with kidney allografts suffered less "decreased-libido, lack of orgasm and no feeling of sex pleasure". Multivariate analyses demonstrated that anemia, depression, and the use of beta-blocker were risk factors for decreased libido. Ageing was a risk factor for "lack of orgasm". The use of r-HuEpo was inversely associated with "lack of orgasm".
Sexual dysfunctions are common in female patients with CRI. The main manifestations are decreased libido, lack of orgasm and no feeling of sex pleasure. The replacement therapy, especially kidney transplantation, could decrease the prevalence or severity of sexual dysfunction. The genesis of sexual dysfunction is multifactorial, including age, physiological factors, psychological factors and medical conditions.
探讨慢性肾功能不全（CRI）女性患者性功能障碍的患病率、主要表现及相关因素。
进行多因素协作横断面研究。采用SCASF Microsoft评估性功能障碍的患病率和严重程度。
CRI患者性功能障碍的患病率高于无肾功能不全者（P<0.05）。女性患者的主要表现为“性欲减退、性高潮缺失及无性快感”。对尿毒症进行分层分析显示，血液透析患者和腹膜透析患者性功能障碍的患病率及严重程度相似。接受肾移植的女性较少出现“性欲减退、性高潮缺失及无性快感”。多因素分析表明，贫血、抑郁和使用β受体阻滞剂是性欲减退的危险因素。年龄增长是“性高潮缺失”的危险因素。使用重组人促红细胞生成素（r-HuEpo）与“性高潮缺失”呈负相关。
性功能障碍在CRI女性患者中很常见。主要表现为性欲减退、性高潮缺失及无性快感。替代治疗，尤其是肾移植，可降低性功能障碍的患病率或严重程度。性功能障碍的发生是多因素的，包括年龄、生理因素、心理因素和医疗状况。
