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早泄:定义和病理生理学的更新。

Premature ejaculation: an update on definition and pathophysiology.

机构信息

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag 82749, Egypt.

Department of Urology, Hamad Medical Corporation and Weill Cornell Medicine-Qatar, Doha 00974, Qatar.

出版信息

Asian J Androl. 2019 Sep-Oct;21(5):425-432. doi: 10.4103/aja.aja_122_18.

DOI:10.4103/aja.aja_122_18
PMID:30860082
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6732885/
Abstract

Premature ejaculation (PE) is the most common male sexual dysfunction, which represents a diagnostic as well as a therapeutic challenge for physicians. However, no universally accepted definition is currently available for PE. As a result, physicians continue to diagnose patients with PE according to major guidelines set by the professional societies. These guidelines either recommend the use of validated questionnaires or patient-reported outcomes. Recent efforts directed toward classifying PE may help provide a better understanding of the prevalence and risk factors of this disorder. While the exact etiology of PE has not been clearly elucidated, several risk factors have been strongly reported in the literature. Clearly, to understand the revised definition of PE, its etiology and pathophysiology is necessary to improve the clinical management of this medical condition and form the basis of future research in this regard. In this review, we highlight the past and current definitions of PE and present an appraisal on the classifications and theories suggested for the etiopathogenesis of PE.

摘要

早泄(PE)是最常见的男性性功能障碍,这对医生来说既是诊断上的挑战,也是治疗上的挑战。然而,目前还没有一个被普遍接受的 PE 定义。因此,医生们继续根据专业协会制定的主要指南来诊断患有 PE 的患者。这些指南要么推荐使用经过验证的问卷,要么推荐使用患者报告的结果。最近针对 PE 的分类工作可能有助于更好地了解这种疾病的流行率和危险因素。虽然 PE 的确切病因尚未明确阐明,但文献中已经强烈报道了一些危险因素。显然,为了理解 PE 的修订定义、病因和病理生理学,有必要改善这种医疗状况的临床管理,并为这方面的未来研究奠定基础。在这篇综述中,我们强调了过去和现在的 PE 定义,并对 PE 的病因发病机制提出的分类和理论进行了评估。

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Premature ejaculation: an update on definition and pathophysiology.早泄:定义和病理生理学的更新。
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2
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本文引用的文献

1
Significance of penile hypersensitivity in premature ejaculation.阴茎超敏在早泄中的意义。
Sci Rep. 2017 Sep 5;7(1):10441. doi: 10.1038/s41598-017-09155-8.
2
Possible role of serum testosterone, gonadotropins and prolactin in patients with premature ejaculation.血清睾酮、促性腺激素和催乳素在早泄患者中的可能作用。
Andrologia. 2018 Feb;50(1). doi: 10.1111/and.12808. Epub 2017 Apr 24.
3
Assessment of hormonal activity in patients with premature ejaculation.早泄患者激素活性的评估。
Int Braz J Urol. 2017 Mar-Apr;43(2):311-316. doi: 10.1590/S1677-5538.IBJU.2016.0064.
4
Premature ejaculation in type II diabetes mellitus patients: association with glycemic control.2型糖尿病患者的早泄:与血糖控制的关联
Transl Androl Urol. 2016 Apr;5(2):248-54. doi: 10.21037/tau.2016.03.11.
5
Premature ejaculation is associated with glycemic control in Type 1 diabetes.早泄与1型糖尿病的血糖控制有关。
J Sex Med. 2015 Jan;12(1):93-9. doi: 10.1111/jsm.12755. Epub 2014 Nov 26.
6
An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE).国际性医学会早泄诊断治疗指南更新版。
Sex Med. 2014 Jun;2(2):60-90. doi: 10.1002/sm2.28.
7
Serum testosterone and gonadotropins levels in patients with premature ejaculation: A comparison with normal men.早泄患者的血清睾酮和促性腺激素水平:与正常男性的比较。
Adv Biomed Res. 2014 Jan 9;3:6. doi: 10.4103/2277-9175.124633. eCollection 2014.
8
A meta-analysis of the effects of the 5-hydroxytryptamine transporter gene-linked promoter region polymorphism on susceptibility to lifelong premature ejaculation.5-羟色胺转运体基因启动子区多态性与终身性早泄易感性的荟萃分析
PLoS One. 2013;8(1):e54994. doi: 10.1371/journal.pone.0054994. Epub 2013 Jan 30.
9
[Study on the correlation of the 5-HTTLPR polymorphism with premature ejaculation in Han Chinese population].[5-羟色胺转运体基因连锁多态性区域(5-HTTLPR)多态性与汉族人群早泄相关性的研究]
Beijing Da Xue Xue Bao Yi Xue Ban. 2011 Aug 18;43(4):514-8.
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International Society for Sexual Medicine's guidelines for the diagnosis and treatment of premature ejaculation.国际性医学会关于早泄的诊断和治疗指南。
J Sex Med. 2010 Sep;7(9):2947-69. doi: 10.1111/j.1743-6109.2010.01975.x.