Vila S B, Peluffo V A, Alvarado C, Cresto J C, Zuccollo A, Catanzaro O L
Cátedra de Fisiología, Facultad de Farmacia y Bioquímica, Hospital General de Niños Dr. Pedro Elizalde, Buenos Aires, Argentina.
Agents Actions Suppl. 1992;38 ( Pt 3):304-10.
The kallikrein-kinin system was studied in 9 normals, healthy subjects (6 men, 3 women, age range 1 to 14 years) and 15 diabetic patients (9 men, 6 women age range 2 to 14 years) with an evolution of the disease between 1 to 14 years. Diabetic patients with low microalbuminuria (6.62 +/- 0.97 mg/24 h) show increased total and pre-kallikrein respect to control (3 and 2 fold respectively). On the other hand patients with high microalbuminuria (44.7 +/- 13.2 mg/24 h) show a total and pre-kallikrein of more than 4 and 8 fold increased respectively, compare with the control. According with these results we can concluded: 1) The total kallikrein and pre-kallikrein is increased in the diabetic state. 2) When microalbuminuria is high, the total and pre-kallikrein correlates with those increasing. 3) These changes could modified the renal hemodynamic in diabetes.
对9名正常健康受试者（6名男性，3名女性，年龄范围为1至14岁）和15名糖尿病患者（9名男性，6名女性，年龄范围为2至14岁，病程为1至14年）的激肽释放酶-激肽系统进行了研究。微量白蛋白尿水平较低（6.62±0.97 mg/24 h）的糖尿病患者，其总激肽释放酶和前激肽释放酶水平相对于对照组有所升高（分别升高了3倍和2倍）。另一方面，微量白蛋白尿水平较高（44.7±13.2 mg/24 h）的患者，其总激肽释放酶和前激肽释放酶水平相对于对照组分别升高了4倍以上和8倍以上。根据这些结果，我们可以得出以下结论：1）糖尿病状态下总激肽释放酶和前激肽释放酶水平升高。2）当微量白蛋白尿水平较高时，总激肽释放酶和前激肽释放酶水平会随之升高。3）这些变化可能会改变糖尿病患者的肾脏血流动力学。
