Zucollo A, Martiarena J, Luna C, Pivetta O, Villagra A, Catanzaro O
Cátedra de Fisiología y Programa de Péptidos, Facultad de Farmacia y Bioquímica, UBA, Argentina.
Agents Actions Suppl. 1992;38 ( Pt 3):493-8.
The mechanisms of kallikrein secretion was studied in 25 normal subjects (11 male, 14 female) and 5 subjects with cystic fibrosis (identified by the usual criteria). The results obtained show a decreasing of prekallikrein and total kallikrein in cystic fibrosis stimulated by IPR or pilocarpine compare to controls. On the other hand sweat from males shows more prekallikrein and total kallikrein than females. According with this results we can concluded that the basic defect in sweat cystic fibrosis gland could be the possible involvement of the kallikrein-kinin system on the high osmolality of the sweat secretion.
在25名正常受试者（11名男性，14名女性）和5名符合通常标准的囊性纤维化患者中研究了激肽释放酶的分泌机制。获得的结果显示，与对照组相比，经异丙肾上腺素或毛果芸香碱刺激后，囊性纤维化患者的前激肽释放酶和总激肽释放酶减少。另一方面，男性汗液中的前激肽释放酶和总激肽释放酶比女性更多。根据这些结果，我们可以得出结论，囊性纤维化汗腺的基本缺陷可能是激肽释放酶-激肽系统参与了汗液分泌的高渗状态。
