Hombal S M, Dincsoy H P
Department of Laboratories, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
Am J Clin Pathol. 1992 Dec;98(6):565-8. doi: 10.1093/ajcp/98.6.565.
Human infection with Pasteurella multocida is the leading cause of animal bite wound infection. Life-threatening infection may occur in patients with a variety of underlying disorders and an immunocompromised state. Infective endocarditis with P. multocida is very rare and only a few clinically diagnosed cases have been reported. Described here is an autopsy case of a 61-year-old man with polycystic kidney disease who had P. multocida bacteremia and acute infective endocarditis with multiple bacterial clumps involving bicuspid aortic valve. The organisms were gram negative. Apparently the sepsis with P. multocida was acquired via licking of leg ulcers by his pet dog, establishing an animal-related causal relationship. Because P. multocida is a very common flora of many animals, infection with this organism probably occurs more frequently than is commonly appreciated. High index of suspicion and early diagnosis, especially in immunocompromised patients, are warranted because the disease is potentially life threatening, yet is a readily treatable infection.
人类感染多杀巴斯德菌是动物咬伤伤口感染的主要原因。患有各种基础疾病和免疫功能低下状态的患者可能会发生危及生命的感染。多杀巴斯德菌引起的感染性心内膜炎非常罕见，仅有少数临床诊断病例的报道。本文描述了一例61岁多囊肾病男性的尸检病例，该患者有多杀巴斯德菌血症和急性感染性心内膜炎，二尖瓣主动脉瓣有多个细菌团块。病原体为革兰阴性菌。显然，多杀巴斯德菌败血症是通过其宠物狗舔舐腿部溃疡而获得的，建立了与动物相关的因果关系。由于多杀巴斯德菌是许多动物中非常常见的菌群，这种病原体引起的感染可能比通常认为的更为频繁。鉴于该疾病具有潜在的生命威胁，但却是一种易于治疗的感染，因此对于免疫功能低下的患者，尤其是高度怀疑和早期诊断是必要的。
