狭叶柴胡中的免疫抑制性黄酮和木脂素。
Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium.
作者信息
Chang Wen-Liang, Chiu Li-Wen, Lai Jenn-Haung, Lin Hang-Ching
机构信息
School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan.
出版信息
Phytochemistry. 2003 Dec;64(8):1375-9. doi: 10.1016/j.phytochem.2003.08.002.
Abstract
Two lignans, isochaihulactone and chaihunaphthone, together with eleven known compounds were isolated from the root of Bupleurum scorzonerifolium. Their structures were established on the basis of spectral evidence. In biological testing, eugenin and saikochromone potently inhibited CD28-costimulated activation of human peripheral blood T cells.
摘要
从狭叶柴胡的根部分离出两种木脂素，异柴胡内酯和柴胡萘酮，以及十一种已知化合物。它们的结构是根据光谱证据确定的。在生物学测试中，尤金宁和柴胡色原酮强烈抑制人外周血T细胞的CD28共刺激活化。
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