Vo Thi Nga, Nguyen Phi Linh, Tuong Lam Truong, Pratt Lawrence Michael, Vo Phung Nguyen, Nguyen Kim Phi Phung, Nguyen Ngoc Suong
Department of Chemical-Food Technology, University of Technical Education-Ho Chi Minh City, 1 Vo Van Ngan Str., Thu Duc Dist., Ho Chi Minh 720059, Vietnam.
Chem Pharm Bull (Tokyo). 2012;60(9):1125-33. doi: 10.1248/cpb.c12-00222.
Two new lignans, pseuderesinol (1), pseuderanoside (2) and a new triterpene, pseuderanic acid (3) were isolated from the dried root of Pseuderanthemum carruthersii (SEEM.) GUILL. var. atropurpureum (BULL.) FOSB. (Acanthaceae), together with ten known compounds, including five lignans, (+)-eudesmin (4), (+)-magnolin (5), (+)-syringaresinol (6), (+)-episyringaresinol (7), (+)-1-hydroxysyringaresinol (8) and five triterpenes, squalene (9), oleanolic acid (10), lupeol (11), betulin (12), betulinic acid (13). Their chemical structures were elucidated by 1D- and 2D-NMR, computational quantum chemistry, as well as high resolution-electrospray ionization (HR-ESI)-MS spectroscopic analysis. The acetylcholinesterase inhibition and cytotoxic activities against HeLa and MCF-7 cancer cell lines were evaluated on some purified compounds at the concentration of 100 µg/mL. Pseuderesinol (1) and magnolin (5) exhibited moderate cytotoxic activities against the MCF-7 cancer cell line.
从假杜鹃（Pseuderanthemum carruthersii (SEEM.) GUILL. var. atropurpureum (BULL.) FOSB.）（爵床科）的干燥根中分离出两种新的木脂素，假芝麻脂素（1）、假芝麻苷（2）和一种新的三萜，假芝麻酸（3），以及十种已知化合物，包括五种木脂素，(+)-桉叶素（4）、(+)-木兰脂素（5）、(+)-紫丁香树脂酚（6）、(+)-表紫丁香树脂酚（7）、(+)-1-羟基紫丁香树脂酚（8）和五种三萜，角鲨烯（9）、齐墩果酸（10）、羽扇豆醇（11）、桦木醇（12）、桦木酸（13）。通过一维和二维核磁共振、计算量子化学以及高分辨率电喷雾电离（HR-ESI）-质谱光谱分析阐明了它们的化学结构。在100 μg/mL的浓度下对一些纯化化合物评估了其对乙酰胆碱酯酶的抑制作用以及对HeLa和MCF-7癌细胞系的细胞毒性活性。假芝麻脂素（1）和木兰脂素（5）对MCF-7癌细胞系表现出中等的细胞毒性活性。
