α2B -肾上腺素能受体的插入/缺失变异似乎不会改变急性心肌梗死的风险，但可能会改变2型糖尿病家族同胞对中患高血压的风险。

The insertion/deletion variation in the alpha2B-adrenoceptor does not seem to modify the risk for acute myocardial infarction, but may modify the risk for hypertension in sib-pairs from families with type 2 diabetes.

作者信息

Snapir Amir, Scheinin Mika, Groop Leif C, Orho-Melander Marju

机构信息

Department of Pharmacology and Clinical Pharmacology, University of Turku, Itäinen Pitkäkatu 4, FIN-20520 Turku, Finland.

出版信息

Cardiovasc Diabetol. 2003 Nov 24;2:15. doi: 10.1186/1475-2840-2-15.

DOI:10.1186/1475-2840-2-15

PMID:14633283

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC305364/

Abstract

BACKGROUND

An insertion/deletion polymorphism in the alpha2B-adrenoceptor (AR) has been associated with the risk for acute myocardial infarction (AMI) and sudden cardiac death. In this study we tested whether this polymorphism is associated with the risk for AMI among members of families with type 2 diabetes.

METHODS

154 subjects with a history of AMI were matched for age and sex with one of their siblings who did not have a history of AMI. The prevalence of the genotypes of the alpha2B-AR insertion/deletion polymorphism was compared between the siblings using McNemar's test. We also explored the data to see whether this genetic variation affects the risk for hypertension by using logistic regression models in the two subpopulations of subjects, with and without a history of AMI.

RESULTS

Among all study subjects, 73 (24%) carried the alpha2B-AR deletion/deletion genotype, 103 (33%) carried the insertion/insertion genotype, and 132 (43%) were heterozygous. The distribution of genotypes of the alpha2B-AR insertion/deletion variation in the group of subjects with a history of AMI and their phenotype-discordant siblings did not statistically significantly differ from that expected by random distribution (p = 0.52): the deletion/deletion genotype was carried by 34 subjects with AMI (22%), and by 39 subjects without AMI (25%). Neither did we observe any significant difference in deletion allele frequencies of the alpha2B-AR insertion/deletion polymorphism between patients with a history of AMI (0.44) and their sib-pair controls (0.46, p = 0.65). In an exploratory analysis, the alpha2B-AR deletion/deletion genotype was associated with increased odds for hypertension compared with subjects carrying any of the other genotypes.

CONCLUSIONS

The deletion/deletion genotype of the alpha2B-AR does not emerge in this study as a risk factor for AMI among members of families with type 2 diabetes; however, it might be involved in the development of hypertension.

摘要

背景

α2B - 肾上腺素能受体（AR）的插入/缺失多态性与急性心肌梗死（AMI）风险及心源性猝死相关。在本研究中，我们测试了这种多态性是否与2型糖尿病家族成员的AMI风险相关。

方法

154例有AMI病史的受试者按年龄和性别与其无AMI病史的一位兄弟姐妹进行匹配。使用McNemar检验比较兄弟姐妹间α2B - AR插入/缺失多态性基因型的患病率。我们还通过在有和无AMI病史的两个亚组受试者中使用逻辑回归模型来探索数据，以查看这种基因变异是否影响高血压风险。

结果

在所有研究对象中，73例（24%）携带α2B - AR缺失/缺失基因型，103例（33%）携带插入/插入基因型，132例（43%）为杂合子。有AMI病史的受试者组及其表型不一致的兄弟姐妹中，α2B - AR插入/缺失变异的基因型分布与随机分布预期无统计学显著差异（p = 0.52）：34例有AMI的受试者（22%）携带缺失/缺失基因型，39例无AMI的受试者（25%）携带该基因型。在有AMI病史的患者（0.44）与其同胞对照（0.46，p = 0.65）之间，我们也未观察到α2B - AR插入/缺失多态性的缺失等位基因频率有任何显著差异。在探索性分析中，与携带任何其他基因型的受试者相比，α2B - AR缺失/缺失基因型与高血压几率增加相关。