Jørgensen M E, Glümer C, Bjerregaard P, Gyntelberg F, Jørgensen T, Borch-Johnsen K
Steno Diabetes Centre, Gentofte, Denmark.
Int J Obes Relat Metab Disord. 2003 Dec;27(12):1507-15. doi: 10.1038/sj.ijo.0802434.
To investigate whether the obesity observed among the Inuit of Greenland and in a general Danish population was associated with the same degree of metabolic disturbances.
Comparison of data from two population-based cross-sectional surveys conducted in 1999-2001.
A total of 7892 individuals aged 30-60 y, 1108 Inuit participants from the Greenland Population study, and 6784 Danish participants in the Danish Inter99 study.
Height, weight, waist and hip circumference were measured, and BMI and waist-to-hip ratio were calculated. The participants received a standard 75 g OGTT. s-Triglyceride, s-HDL cholesterol, fasting and 2 h p-glucose and s-insulin were analysed. Blood pressure was measured. Information on lifestyle factors was obtained by a questionnaire and interview.
The Inuit had lower levels of 2-h glucose and insulin, blood pressure, triglyceride, and higher levels of HDL cholesterol than the Danish participants at any given level of obesity. Fasting glucose and fasting insulin levels within obesity categories were not different in the two populations. Adjustment for physical activity, smoking, school education, and alcohol consumption did not change these findings.
The trends in the association between obesity and metabolic effects among the Inuit and a Northern European population were the same, but the levels of the risk factors were significantly different. This may be due to genetic factors and differences in body composition.
调查格陵兰因纽特人和丹麦普通人群中观察到的肥胖是否与相同程度的代谢紊乱相关。
对1999 - 2001年进行的两项基于人群的横断面调查数据进行比较。
共7892名年龄在30 - 60岁的个体，1108名来自格陵兰人群研究的因纽特参与者，以及6784名丹麦Inter99研究的丹麦参与者。
测量身高、体重、腰围和臀围，并计算体重指数（BMI）和腰臀比。参与者接受标准的75克口服葡萄糖耐量试验（OGTT）。分析血清甘油三酯、血清高密度脂蛋白胆固醇、空腹和2小时血糖以及血清胰岛素。测量血压。通过问卷调查和访谈获取生活方式因素信息。
在任何给定肥胖水平下，因纽特人的2小时血糖和胰岛素水平、血压、甘油三酯水平均低于丹麦参与者，而高密度脂蛋白胆固醇水平高于丹麦参与者。在肥胖类别中，两个群体的空腹血糖和空腹胰岛素水平没有差异。对体力活动、吸烟、学校教育和饮酒进行调整后，这些结果没有改变。
因纽特人和北欧人群中肥胖与代谢效应之间的关联趋势相同，但危险因素水平存在显著差异。这可能是由于遗传因素和身体组成的差异。
