Huo Teh-Ia, Wu Jaw-Ching, Wu Shiow-Ing, Chang An-Lung, Lin Shih-Ku, Pan Chun-Hung, Huang Yi-Hsiang, Chang Full-Young, Lee Shou-Dong
Department of Medicine, Division of Gastroenterology, Taipei Veterans General Hospital and Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taiwan.
J Med Virol. 2004 Jan;72(1):41-5. doi: 10.1002/jmv.10554.
Needle-sharing and sexual contact are important transmission routes of hepatitis B, C, and D virus (HBV, HCV, HDV) infection. This study aimed to investigate the current status of these viral infections among high-risk populations including prostitutes and intravenous (i.v.) drug users, compared with the prevalence rate reported previously to examine the changing seroepidemiology. Of the 916 female prostitutes, 79 (9%) were positive for antibody to HCV (anti-HCV), 111 (12%) were positive for HBV surface antigen (HBsAg), and 5 (5%) had antibody to HDV (anti-HDV). The prevalence rate was significantly lower compared to that in 1989-1991 (12%, P = 0.037) for HCV infection, and to that in 1988 (59%) and 1996 (40%) (P < 0.0001) for HDV infection. Of the 494 i.v. drug users, 87 (18%) patients were HBsAg carriers and 12 (14%) were anti-HDV-positive. The prevalence rate of HDV infection was significantly lower than that reported in 1985 (79%, P < 0.0001). Among the 443 tested i.v. drug users, 182 (41%) were anti-HCV-positive, significantly lower than that in 1985 (53%, P = 0.026). Of the 263 male prostitutes, 11 (4%) were anti-HCV-positive, 45 (17%) were HBsAg-positive, and 7 (16%) were anti-HDV-positive. Of the 129 illegal immigrant prostitutes, 7 (5%) were anti-HCV-positive, 15 (12%) were HBsAg-positive and none were positive for anti-HDV. In conclusion, the findings indicate a declining prevalence of HCV and HDV infections among drug users and prostitutes over the past 16 years. Male prostitutes and immigrant prostitutes are new "high-risk" populations and may become a reservoir for disease transmission.
共用针头和性接触是乙肝、丙肝和丁型肝炎病毒（HBV、HCV、HDV）感染的重要传播途径。本研究旨在调查包括妓女和静脉注射吸毒者在内的高危人群中这些病毒感染的现状，并与之前报道的患病率进行比较，以研究血清流行病学的变化情况。在916名女性妓女中，79人（9%）抗-HCV阳性，111人（12%）HBsAg阳性，5人（5%）抗-HDV阳性。与1989 - 1991年（12%，P = 0.037）相比，HCV感染患病率显著降低；与1988年（59%）和1996年（40%）相比，HDV感染患病率显著降低（P < 0.0001）。在494名静脉注射吸毒者中，87名（18%）患者为HBsAg携带者，12名（14%）抗-HDV阳性。HDV感染患病率显著低于1985年报道的患病率（79%，P < 0.0001）。在443名接受检测的静脉注射吸毒者中，182名（41%）抗-HCV阳性，显著低于1985年（53%，P = 0.026）。在263名男性妓女中，11人（4%）抗-HCV阳性，45人（17%）HBsAg阳性，7人（16%）抗-HDV阳性。在129名非法移民妓女中，7人（5%）抗-HCV阳性，15人（12%）HBsAg阳性，无人抗-HDV阳性。总之，研究结果表明，在过去16年中，吸毒者和妓女中HCV和HDV感染患病率呈下降趋势。男性妓女和移民妓女是新的“高危”人群，可能成为疾病传播的传染源。
