骨巨细胞瘤来源的破骨细胞样细胞的功能与生化特性
Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone.
作者信息
Grano M, Colucci S, Portoghese A, Zambonin G, Barattolo R, Serra M, Scotlandi K, Teti A, Zambonin Zallone A
机构信息
Istituto di Citomorfologia Normale e Patologica, Università di Chieti.
出版信息
Boll Soc Ital Biol Sper. 1992 Apr;68(4):249-53.
Cells harvested from human giant cell tumours of bone were characterized on the basis of morphological features, proliferative capacity, total(AP) and tartrate resistant acid phosphatase (TRAP) activity, and hormonal response. Culture were formed by mononucleated and multinucleated cells. Mononucleated cells showed fibroblastic morphology, whereas multinucleated cells showed osteoclastic phenotype. We conclude that in these cultures mature osteoclasts and their mononuclear precursors are present.
从人骨巨细胞瘤中获取的细胞，根据其形态特征、增殖能力、总酸性磷酸酶（AP）和抗酒石酸酸性磷酸酶（TRAP）活性以及激素反应进行了表征。培养物由单核细胞和多核细胞组成。单核细胞呈现成纤维细胞形态，而多核细胞呈现破骨细胞表型。我们得出结论，在这些培养物中存在成熟破骨细胞及其单核前体。
Zotero 插件