Rybakowski Janusz K, Borkowska Alina, Czerski Piotr M, Skibińska Maria, Hauser Joanna
Department of Adult Psychiatry, University of Medical Sciences, Poznan, Poland.
Bipolar Disord. 2003 Dec;5(6):468-72. doi: 10.1046/j.1399-5618.2003.00071.x.
The aim of the study was to test a possible association between the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene and performance on a neurocognitive test, the Wisconsin Card Sorting Test (WCST), in bipolar patients.
Fifty-four bipolar patients were studied, 18 male and 36 female, aged 18-72 (mean 46 years). The number of perseverative errors (WCST-P), non-perseverative errors (WCST-NP), completed corrected categories (WCST-CC), conceptual level responses (WCST-%CONC) and set to the first category (WCST-1st CAT) were measured in relation to the Val66Met genotypes of BDNF.
The percentages of subjects with Val/Val, Val/Met and Met/Met genotypes were respectively 81.5, 16.7 and 1.8%. Subjects with Val/Val and Val/Met genotypes did not differ on clinical factors except for the age of onset of the illness, which was earlier in Val/Val than Val/Met genotype (27 years versus 38 years). The performance in all domains of WCST was significantly better in subjects with Val/Val BDNF genotype compared with Val/Met genotype.
The results suggest a role of BDNF in prefrontal cognitive function in bipolar illness. The tests of prefrontal cognition may be considered as endophenotypic markers in bipolar illness.
本研究旨在检测双相情感障碍患者脑源性神经营养因子（BDNF）基因的Val66Met多态性与神经认知测试——威斯康星卡片分类测试（WCST）表现之间可能存在的关联。
对54例双相情感障碍患者进行研究，其中男性18例，女性36例，年龄18 - 72岁（平均46岁）。针对BDNF的Val66Met基因型，测量持续性错误数（WCST - P）、非持续性错误数（WCST - NP）、完成的校正分类数（WCST - CC）、概念水平反应数（WCST - %CONC）以及对第一类的设定（WCST - 1st CAT）。
Val/Val、Val/Met和Met/Met基因型受试者的百分比分别为81.5%、16.7%和1.8%。Val/Val和Val/Met基因型受试者在临床因素上无差异，但疾病起病年龄除外，Val/Val基因型患者的起病年龄早于Val/Met基因型患者（27岁对38岁）。与Val/Met基因型相比，BDNF基因Val/Val型受试者在WCST所有领域的表现均显著更好。
结果表明BDNF在双相情感障碍的前额叶认知功能中发挥作用。前额叶认知测试可被视为双相情感障碍的内表型标志物。
