Bolat Kaya Özlem, Kaya Hasan, Civan Kahve Aybeniz, Enez Darçin Aslı, Yalçin Çavuş Raziye Serçin, Dilbaz Nesrin
Psychiatrist at Private Practice, Ankara, Turkey.
Department of Psychiatry, University of Health Sciences Ankara City Hospital, Ankara, Turkey.
Noro Psikiyatr Ars. 2022 Feb 17;59(2):91-97. doi: 10.29399/npa.27647. eCollection 2022.
The relationship between BDNF gene Val/Met polymorphism and clinical symptoms, attention and executive functions in patients with schizophrenia was investigated in this study. Also, BDNF Val66Met gene polymorphism was compared between patients and healthy controls. Thus, genetic factors that may affect both the etiology and cognitive functions in schizophrenia were evaluated.
BDNF Val66Met gene polymorphism was investigated in 102 patients with schizophrenia and 98 healthy controls. Cognitive functions were evaluated by the Wisconsin Card Sorting Test (WCST) and Stroop Test.
There was no difference in terms of the genotypic or allelic distribution of BDNF Val66Met polymorphism between patients and healthy controls. A significantly higher percentage of suicide attempts were found in the patients having Met allele (Val/Met and Met/Met). Met allele was associated with failure in focused attention and response inhibition in patients with schizophrenia.
The presence of the Met allele could be associated with the risk of suicide attempts in patients with schizophrenia. Impairment in executive function areas such as focused attention and response inhibition appears to be related to the Met allele.
本研究调查了精神分裂症患者脑源性神经营养因子（BDNF）基因Val/Met多态性与临床症状、注意力及执行功能之间的关系。此外，还比较了患者与健康对照之间BDNF Val66Met基因多态性。因此，对可能影响精神分裂症病因及认知功能的遗传因素进行了评估。
对102例精神分裂症患者和98名健康对照进行BDNF Val66Met基因多态性检测。通过威斯康星卡片分类测验（WCST）和斯特鲁普测验评估认知功能。
患者与健康对照之间BDNF Val66Met多态性的基因型或等位基因分布无差异。携带Met等位基因（Val/Met和Met/Met）的患者自杀未遂比例显著更高。Met等位基因与精神分裂症患者集中注意力和反应抑制功能障碍有关。
Met等位基因的存在可能与精神分裂症患者自杀未遂风险有关。集中注意力和反应抑制等执行功能领域的损害似乎与Met等位基因有关。
