Gölander C G, Lassen B, Nilsson-Ekdahl K, Nilsson U R
Institute for Surface Chemistry, Stockholm, Sweden.
J Biomater Sci Polym Ed. 1992;4(1):25-30.
Five different plasma modified surfaces were made for studying different aspects of biocompatibility. These surfaces were: 1,2-diaminocyclohexane (DACH), acrylic acid (AA), Hydroxyethylmethacrylate (HEMA), methane and hexamethylene-disiloxane (HMDSO). In addition a polyethylene-glycol (PEG) was made by grafting aldehyde functional PEG to the DACH surface. PEG and HMDSO which are the most hydrophilic and the most hydrophobic surface shows the lowest amount of adsorbed protein of the three proteins studied here (albumin, IgG and C3). Methane, HMDSO and HEMA was found to activate via the classical (complement activation) pathway while the others activated via the alternative pathway.
制备了五种不同的等离子体改性表面，用于研究生物相容性的不同方面。这些表面分别是：1,2 - 二氨基环己烷（DACH）、丙烯酸（AA）、甲基丙烯酸羟乙酯（HEMA）、甲烷和六甲基二硅氧烷（HMDSO）。此外，通过将醛基功能化的聚乙二醇（PEG）接枝到DACH表面制备了一种聚乙二醇（PEG）。PEG和HMDSO分别是最亲水和最疏水的表面，在所研究的三种蛋白质（白蛋白、IgG和C3）中显示出最低的蛋白质吸附量。发现甲烷、HMDSO和HEMA通过经典（补体激活）途径激活，而其他物质通过替代途径激活。
