Kondo Ryoichi, Haniuda Masayuki, Yamanda Takeshi, Sato Etsuro, Fujimoto Keisaku, Kubo Keishi, Amano Jun
Department of Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
Respir Physiol Neurobiol. 2003 Dec 16;139(1):33-40. doi: 10.1016/j.resp.2003.09.011.
The measurements of exhaled nitric oxide (ENO) concentrations in several previous reports have been quite disparate but the cause of this variability is unclear. In the present study, we have attempted to elucidate the effects of expiratory pressure upon ENO values by taking measurements at pressures ranging from 2 to 10 cmH2O in control subjects and in both smokers and asthmatics. Differences in ENO concentrations (delta pNO) were then estimated and the concentration levels were found to increase with elevated expiratory pressure levels in both the control volunteers and in the asthmatics (under 2 and 3 L/min flow rates). These results indicate that changes in expiratory pressure indeed affect ENO concentrations. The measurement of ENO concentrations in human patients must therefore be undertaken using standard procedures that must incorporate expiratory pressure levels in order to properly interpret ENO values.
在先前的几份报告中，呼出一氧化氮（ENO）浓度的测量结果差异颇大，但这种变异性的原因尚不清楚。在本研究中，我们试图通过在对照受试者以及吸烟者和哮喘患者中，于2至10 cmH₂O的压力范围内进行测量，来阐明呼气压力对ENO值的影响。然后估算了ENO浓度的差异（δpNO），结果发现，在对照志愿者和哮喘患者中（流量低于2和3 L/分钟），浓度水平均随呼气压力水平的升高而增加。这些结果表明，呼气压力的变化确实会影响ENO浓度。因此，在人类患者中测量ENO浓度时，必须采用标准程序，这些程序必须纳入呼气压力水平，以便正确解读ENO值。
