Schrag Anette, Hovris Anna, Morley David, Quinn Niall, Jahanshahi Marjan
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College, London, United Kingdom.
Mov Disord. 2003 Nov;18(11):1250-6. doi: 10.1002/mds.10527.
The effect of Parkinson's disease (PD) on young patients' lives is likely to differ from that in older patients. For this study, 75 patients with onset of PD before the age of 50 and 66 patients with later onset completed a booklet of questionnaires on demographic and clinical variables, quality of life, and psychosocial factors. Apart from a higher rate of treatment-related dyskinesias in the younger onset group, the two groups did not differ in self-reported disease severity or disability. A higher percentage of young-onset patients was unemployed due to disability or had retired early. Quality of life as measured on the PDQ-39 was significantly worse in young-onset patients than in older-onset patients. Young-onset patients also had worse scores on the stigma and marital satisfaction scales, and were depressed more frequently. Differences between the two groups in their most commonly employed coping strategies and in terms of their satisfaction with emotional support did not reach significance. We conclude that young-onset patients more frequently experience loss of employment, disruption of family life, greater perceived stigmatization, and depression than do older-onset patients with PD. In addition to more severe treatment-related motor complications, social and psychosocial factors may contribute to greater impairment of quality of life in young patients with PD.
帕金森病（PD）对年轻患者生活的影响可能与老年患者不同。在本研究中，75例50岁之前发病的PD患者和66例较晚发病的患者完成了一本关于人口统计学和临床变量、生活质量及心理社会因素的问卷册。除了年轻发病组中与治疗相关的运动障碍发生率较高外，两组在自我报告的疾病严重程度或残疾方面并无差异。较高比例的年轻发病患者因残疾而失业或提前退休。用PDQ - 39量表测得的年轻发病患者的生活质量显著低于老年发病患者。年轻发病患者在耻辱感和婚姻满意度量表上的得分也更低，且更频繁地出现抑郁情绪。两组在最常用的应对策略以及对情感支持的满意度方面的差异未达到显著水平。我们得出结论，与老年发病的PD患者相比，年轻发病患者更频繁地经历失业、家庭生活 disrupted（此处原文可能有误，推测为“受干扰”之类意思）、更强的耻辱感以及抑郁情绪。除了更严重的与治疗相关的运动并发症外，社会和心理社会因素可能导致年轻PD患者的生活质量受损更严重。
