Eur J Cancer Prev. 1992 Feb;1(2):177-86. doi: 10.1097/00008469-199202000-00011.
A case-control study has been carried out on 129 patients with newly diagnosed intestinal metaplasia (IM) recruited in four UK centres (London, Slough, Stoke and Glasgow). Serum assays of a range of vitamins demonstrated that 38% of IM patients had serum ascorbic acid levels below the detection levels compared with only 16% of controls free of chronic gastric lesions; this difference was also seen in the patients from the individual centres. There were no major differences between cases and controls in any other serum vitamin levels measured (carotene, tocopherol or the ratio of tocopherol to cholesterol). Comparison of the healthy asymptomatic controls suggested that the intakes of ascorbic acid and of beta-carotene were much higher in southern England than in Stoke or Glasgow. The tocopherol status in the four centres tended to be more similar.
在英国四个中心（伦敦、斯劳、斯托克和格拉斯哥）招募了129例新诊断为肠化生（IM）的患者，开展了一项病例对照研究。一系列维生素的血清检测显示，38%的IM患者血清抗坏血酸水平低于检测水平，而无慢性胃部病变的对照组中这一比例仅为16%；各个中心的患者中也存在这一差异。所检测的其他血清维生素水平（胡萝卜素、生育酚或生育酚与胆固醇的比值）在病例组和对照组之间没有显著差异。对健康无症状对照组的比较表明，英格兰南部抗坏血酸和β-胡萝卜素的摄入量远高于斯托克或格拉斯哥。四个中心的生育酚状况较为相似。
