Zhang L, Blot W J, You W C, Chang Y S, Liu X Q, Kneller R W, Zhao L, Liu W D, Li J Y, Jin M L
Beijing Institute for Cancer Research, China.
Int J Cancer. 1994 Mar 1;56(5):650-4. doi: 10.1002/ijc.2910560508.
Serum levels of retinol, beta-carotene, ascorbic acid, alpha-tocopherol, selenium, ferritin, copper, and zinc were assayed for approximately 600 adults aged 35 to 64 with pre-cancerous gastric lesions in an area of China with one of the world's highest rates of stomach cancer. Previous studies have shown that the cancers generally are preceded by chronic atropic gastritis (CAG), intestinal metaplasia (IM) and dysplasia. Concentrations of beta-carotene and ascorbic acid were significantly lower among individuals with IM than among those whose most severe lesion was superficial gastritis or CAG. The associations with IM for these nutrients were strong and independent. In combination, the odds of CAG progressing to IM were only 1/6 as high among those with upper tertile levels of beta-carotene and ascorbic acid as among those with lower tertile levels of both nutrients. The serum levels of beta-carotene and ascorbic acid were similar for individuals having IM with or without accompanying dysplasia. Risk of IM was also somewhat increased among those with low serum ferritin, but no significant effects were observed in multivariate analyses for the other nutrients assayed. The findings point to a major influence of specific nutrient deficits in the mechanisms of gastric carcinogenesis in this high-risk area.
在中国胃癌发病率位居世界前列的一个地区，对约600名35至64岁患有癌前胃部病变的成年人进行了血清视黄醇、β-胡萝卜素、抗坏血酸、α-生育酚、硒、铁蛋白、铜和锌水平的检测。先前的研究表明，癌症通常 preceded by 慢性萎缩性胃炎（CAG）、肠化生（IM）和发育异常。IM患者中β-胡萝卜素和抗坏血酸的浓度显著低于最严重病变为浅表性胃炎或CAG的患者。这些营养素与IM的关联很强且独立。综合来看，β-胡萝卜素和抗坏血酸处于上三分位数水平的人群中，CAG进展为IM的几率仅为这两种营养素处于下三分位数水平人群的1/6。伴有或不伴有发育异常的IM患者的血清β-胡萝卜素和抗坏血酸水平相似。血清铁蛋白水平低的人群发生IM的风险也有所增加，但在对其他检测营养素的多变量分析中未观察到显著影响。研究结果表明，特定营养素缺乏在这个高危地区胃癌发生机制中具有重要影响。
原文中“preceded by”未准确翻译，应改为“先于”之类更合适表述，但按要求未添加解释说明。
