氯乙烯与大鼠肝微粒体细胞色素P-450的体外相互作用。 - Suppr

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The interaction of vinyl chloride with rat hepatic microsomal cytochrome P-450 in vitro.

作者信息

Ivanetich K M, Aronson I, Katz I D

出版信息

Biochem Biophys Res Commun. 1977 Feb 21;74(4):1411-8. doi: 10.1016/0006-291x(77)90599-x.

DOI:10.1016/0006-291x(77)90599-x

PMID:14640

Abstract

摘要

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The interaction of vinyl chloride with rat hepatic microsomal cytochrome P-450 in vitro.氯乙烯与大鼠肝微粒体细胞色素P-450的体外相互作用。

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Contrasting effects of 1,1,1-trichloroethane on [14C]vinyl chloride metabolism and activation in hepatic microsomes from phenobarbital- and isoniazid-treated rats.1,1,1-三氯乙烷对苯巴比妥和异烟肼处理大鼠肝微粒体中[14C]氯乙烯代谢及活化的对比作用。

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Possible mechanism of induction of liver microsomal monooxygenases by phenobarbital.苯巴比妥诱导肝微粒体单加氧酶的可能机制。

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引用本文的文献

Induction of rat liver drug-metabolizing enzymes by tetrachloroethylene.四氯乙烯对大鼠肝脏药物代谢酶的诱导作用。

Arch Environ Contam Toxicol. 1995 Apr;28(3):273-80. doi: 10.1007/BF00213102.

Monooxygenase activity and ultrastructural changes of liver in the course of chronic exposure of rats to vinyl chloride.大鼠长期接触氯乙烯过程中肝脏的单加氧酶活性及超微结构变化

Int Arch Occup Environ Health. 1980;46(3):241-9. doi: 10.1007/BF00380014.

The effect of fluroxene [(2,2,2-trifluoroethoxy)ethane] on haem biosynthesis and degradation.氟烷（[2,2,2-三氟乙氧基]乙烷）对血红素生物合成及降解的影响。

Biochem J. 1980 Sep 15;190(3):571-80. doi: 10.1042/bj1900571.

Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.啮齿动物或人类肝脏组织产生的卤代乙烯、氯丁二烯和二氯丁烯的诱变和烷基化代谢产物。细胞色素P450相关微粒体单加氧酶形成环氧乙烷的证据。

Arch Toxicol. 1979 Feb 23;41(4):249-77. doi: 10.1007/BF00296896.

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