Borzutzky Arturo, Avello Esteban, Rumie Hana, Paris Enrique
Catholic University School of Medicine, Santiago, Chile.
Vet Hum Toxicol. 2003 Dec;45(6):309-10.
Clozapine is a tricyclic dibenzodiazepine derivative used commonly in the treatment of schizophrenia. Severe side effects of overdose have been described in children. This report describes the unintentional ingestion of clozapine by a 10-y-o girl, presenting dramatic changes of mental status and progressive alteration of consciousness with a Glasgow Coma Scale drop from 12 to 7. Urine analysis revealed 500 microg clozapine/L 24 h after ingestion. Full resolution of symptoms occurred after approximately 55 h with no sequels or alterations at follow-up. Awareness must be taken when administering atypical antipsychotics such as clozapine to children because of the severe intoxication effects cases reported.
氯氮平是一种三环二苯并二氮䓬衍生物，常用于治疗精神分裂症。儿童过量服用氯氮平会出现严重副作用。本报告描述了一名10岁女孩意外摄入氯氮平的情况，她出现了精神状态的剧烈变化和意识的进行性改变，格拉斯哥昏迷评分从12降至7。尿液分析显示摄入后24小时氯氮平含量为500微克/升。约55小时后症状完全缓解，随访时无后遗症或改变。由于有儿童服用氯氮平这类非典型抗精神病药物导致严重中毒的病例报道，因此在给儿童使用此类药物时必须提高警惕。
