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Pediatric clozapine intoxication.

作者信息

Mady S, Wax P, Wang D, Goetz C, Hadley C, Love R

机构信息

Department of Emergency Medicine, University of Rochester, USA.

出版信息

Am J Emerg Med. 1996 Sep;14(5):462-3. doi: 10.1016/S0735-6757(96)90152-7.

DOI:10.1016/S0735-6757(96)90152-7
PMID:8765110
Abstract

Clozapine is a tricyclic dibenzodiazepine derivative used as an antipsychotic in adults. Clozapine's safety in children has not been established. This report describes three unintentional clozapine ingestions in pediatric patients. These are the first reported cases of clozapine intoxication in children. All three patients demonstrated dramatic alterations in mental status and tone, and two demonstrated extrapyramidal effects. Serum clozapine levels obtained in two patients were within the average range of steady state plasma concentrations for adults. These cases show the dramatic presentations of pediatric ingestion of clozapine and the differences between adult and pediatric intoxications.

摘要

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