来自苏利亚猴欢喜的细胞毒性葫芦素成分。

Cytotoxic cucurbitacin constituents from Sloanea zuliaensis.

作者信息

Rodriguez Nelson, Vasquez Yelkaira, Hussein Ahmed A, Coley Phyllis D, Solis Pablo N, Gupta Mahabir P

机构信息

Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panamá, República de Panamá.

出版信息

J Nat Prod. 2003 Nov;66(11):1515-6. doi: 10.1021/np0303106.

DOI:10.1021/np0303106

PMID:14640532

Abstract

A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.

摘要

从苏利亚南美厚壳树（Sloanea zuliaensis）中分离出一种新的葫芦素D类似物2-脱氧葫芦素D（1）以及葫芦素D（2）和25-乙酰基葫芦素F（3）。化合物1仅在该植物的幼叶中发现，成熟叶中未发现，其结构通过光谱手段确定。化合物1-3对人乳腺癌（MCF-7）、肺癌（H-460）和中枢神经系统癌（SF-268）细胞系表现出强大的细胞毒性活性。