美登木中的细胞毒三萜。
Cytotoxic triterpenoids from Maytenus retusa.
机构信息
Instituto Universitario de Bio-Orgánica Antonio González, Avenida Astrofísico Francisco Sánchez 2, La Laguna, Tenerife, Spain.
出版信息
J Nat Prod. 2010 Dec 27;73(12):2029-34. doi: 10.1021/np100517u. Epub 2010 Nov 23.
PMID:21090801
Abstract
Seven new triterpenoids (1-7) and 36 known compounds were isolated from the root bark of Maytenus retusa. Their structures were determined by 1D and 2D spectroscopic studies. Several compounds were evaluated for their cytotoxicity against the human tumor cell lines HL-60 and MCF-7. Some of them were cytotoxic, with IC(50) values ranging between 0.2 and 4.7 μM.
摘要
从短叶水团木的根皮中分离得到了 7 个新的三萜类化合物（1-7）和 36 个已知化合物。通过一维和二维光谱研究确定了它们的结构。对几种化合物进行了人肿瘤细胞系 HL-60 和 MCF-7 的细胞毒性评价。其中一些具有细胞毒性，IC50 值在 0.2 到 4.7 μM 之间。
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