Dostál C, Kölblová V, Nouza K
Revmatologický ústav, Praha.
Cas Lek Cesk. 1992 Oct 9;131(19):582-7.
The authors summarize contemporary views on the relationship between pregnancy and systemic lupus erythematosus (SLE) in women of reproductive age. It is known that pregnancy influences in a marked way the basic disease and conversely the disease has an impact on the course of pregnancy. Risks ensuing from these in errelations for women--mothers with SLE and the foetus are exacerbation (flare-up) of the basic disease, loss of the foetus and damage of the foetus by so-called "lupus neonatorum" with skin symptoms and complete cardiac A-V block. The contemporary state of knowledge makes it possible under certain conditions to achieve by therapeutic interventions the development and delivery of a healthy foetus. Among these views it is most important for conception to occur in these patients with SLE during a period without signs of active SLE. To ensure a successful course of pregnancy in women with SLE is the task of a team of appropriate specialists.
作者总结了当代关于育龄女性妊娠与系统性红斑狼疮(SLE)之间关系的观点。众所周知,妊娠对基础疾病有显著影响,反之,疾病也会影响妊娠过程。这些相互关系给患有SLE的女性——母亲及其胎儿带来的风险包括基础疾病的加重(病情发作)、胎儿丢失以及所谓的“新生儿狼疮”导致的胎儿损伤,后者伴有皮肤症状和完全性心脏房室传导阻滞。当代的知识水平使得在某些条件下通过治疗干预实现健康胎儿的发育和分娩成为可能。在这些观点中,对于患有SLE的患者来说,最重要的是在无SLE活动迹象的时期受孕。确保患有SLE的女性妊娠顺利是一组合适的专科医生的任务。