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Effects of 32-oxygenated lanosterol derivatives on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis from 24,25-dihydrolanosterol.

作者信息

Sonoda Y, Obi N, Onoda M, Sakakibara Y, Sato Y

机构信息

Kyoritsu College of Pharmacy, Tokyo, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1992 Oct;40(10):2796-9. doi: 10.1248/cpb.40.2796.

DOI:10.1248/cpb.40.2796
PMID:1464112
Abstract

The effects of 32-oxygenated lanosterol derivatives on 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and cholesterol biosynthesis from [24,25-3H]24,25-dihydrolanosterol were studied. Among the derivatives, 3 beta-hydroxylanost-7-en-32-oic acid was the most active in depressing HMG-CoA reductase activity (IC50: 0.7 microM) and cholesterol biosynthesis (IC50: 0.4 microM) from 24,25-dihydrolanosterol.

摘要

相似文献

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